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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 13 (1930), S. 1292-1308 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 701 (1967), S. 225-232 
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus den vier isomeren Diacetylbenzolglykol-epoxiden (Diacetoxycyclohexenepoxiden) 1, 7, 12 und 17 wurden kristalline Derivate von sechs isomeren Inosit-monophosphaten 4, 9, 10, 16, 19 und 21 dargestellt. Die Strukturen folgen durch Abbau zum Inosit, aus der Synthese und den NMR-Spektren der Acetylderivate.
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  • 3
    ISSN: 0268-2605
    Keywords: Dimethylarsinic acid ; two-stage carcinogenesis ; carcinogenicity ; urinary bladder ; multi-organ carcinogenesis promotion ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The modifying effects of dimethylarsinic acid (DMA) on tumor induction in various organs were examined using a multi-organ rat carcinogenesis bioassay. A total of 124 six-week-old male F344/DuCrj rats were divided randomly into seven groups. For establishment of wide-spectrum initiation, animals in Groups 1-5 were treated with five carcinogens, namely N-nitrosodiethylamine (DEN), N-methyl-N-nitrosourea (MNU), 1,2-dimethylhydrazine (DMH), N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) and N-bis(2-hydroxypropyl)nitrosamine (DHPN) in the first four weeks. After a two-week interval, Groups 1-5 were then given 0, 50, 100, 200 and 400 ppm DMA, respectively, in drinking water. Groups 6 and 7 received 100 and 400 ppm DMA without any carcinogen pretreatment. All rats were sacrificed at the end of week 30. In the initiated groups (Groups 1-5), DMA enhanced tumor development in the urinary bladder, kidney, liver and thyroid gland. The main arsenic species in urine samples was DMA itself. In conclusion, the observed enhancement of carcinogenesis in the urinary tract as well as in the liver and thyroid gland may be directly due to this arsenic compound.
    Additional Material: 1 Ill.
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 4 (1990), S. 181-190 
    ISSN: 0268-2605
    Keywords: Arsenic speciation ; marine algae ; arsenosugar ; arsenolipid ; HPLC/ICP ; methylarsenic ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical forms of water-soluble and lipid soluble arsenic compounds in marine macroalgae, including edible algae, are reviewed. Major watersoluble arsenic compounds inalgae are arseniccontaining ribofuranosides (ACRs). Red and green algae contain mainly a glycerophospho derivative at the glycerol terminal while brown algae contain a sulfate or sulfonate derivatives at the glycerol terminal together with a glycerophospho derivative. Brown algae which belong to the Sargasso species contain significant amounts of inorganic arsenic in the form of arsenate. Lipid-soluble arsenic identified in a brown algae (Undaria pinnatifida) was an acylated derivative of an ACR. Thirty-eight marine algae were analyzed by HPLC/ICP/MS and their arsenic compounds are characterized. The characterization of arsenic compounds may show their role in the chemical taxonomy of algae species in addition to giving an understanding of the toxicological and geochemical implication of the element.
    Additional Material: 2 Ill.
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 8 (1994), S. 249-251 
    ISSN: 0268-2605
    Keywords: HPLC—ICP MS ; arsenic speciation ; arsenobetaine ; human blood ; plasma ; serum ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Arsenobetaine was detected and quantified unambiguously in human plasma, serum and red blood cells by the combination of HPLC with ICP MS. Three different column conditions, i.e. two ionpair chromatographies for anionic (LC-1) and cationic (LC-2) compounds and gel-permeation chromatography (LC-3), were employed to confirm the assignment. Arsenobetaine was detected in every sample as a major component of the water-soluble arsenic compounds, with an increasing concentration in plasma 〈 serum 〈 blood cell fractions. It was the sole detectable arsenic compound in LC-1 and LC-2, while a broad peak corresponding to high-molecular-weight compounds was identified in addition to arsenobetaine in LC-3.
    Additional Material: 1 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 4 (1990), S. 255-260 
    ISSN: 0268-2605
    Keywords: Arsenic-containing ribofuranosides ; arsenosugars ; high-performance liquid chromatography ; inductively coupled plasma mass spectrometry ; red alga ; Porphyra tenera ; nori ; yakinori ; hydride generation-atomic absorption spectrometry ; methylarsenate compounds ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Arsenic compounds were extracted with methanol/water (1:1, v/v) from freeze-dried samples of the edible red alga, Porphyra tenera (asakusanori in Japanese), and also from nori and yakinori, food items produced from red algae. The extracts were analyzed by high-performance liquid chromatography (HPLC) with an inductively coupled plasma mass spectrometer (ICPMS) serving as an arsenic-specific detector. Two arsenic-containing ribofuranosides were identified in all samples tigated, and they accounted for almost all the extractable arsenic (8.7-21 mg As Kg-1 dry sample) in each sample. A compound bearing a glycer-ophosphoryl glycerol moiety was dominant in every sample. Arsenite, arsenate, methylarsonate, and dimethylarsinate were quantified by hydride generation and atomic absorption spectrometry. Arsenate and dimethylarsinate were detected in all samples at low levels (around 0.15 and 0.05 mg As Kg-1 dry sample, respectively). Arsenite was detected only in the unprocessed Porphyra tenera at 0.005 mg As Kg-1 dry sample. Methylarsonate was not found in any of the samples.
    Additional Material: 4 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 2 (1988), S. 365-369 
    ISSN: 0268-2605
    Keywords: Arsenic ; seaweed ; Codium fragile ; arsenic-containing ribofuranosides ; dimethylarsinic acid ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three water-soluble arsenic compounds were isolated from the green seaweed Codium fragile. These compounds were identified as 1-glycerophosphoryl-2-hydroxy-3-[5′-deoxy-5′-(dimethylarsinoyl)-β-ribofuranosyloxy]propane (1a), 1′ -(1,2-dihydroxypropyl)-5′ -deoxy-5′ -(dimethylarsinoyl)-β-ribofuranoside (1b), and dimethylarsinic acid ((CH3)2AsOOH). The structures of these compounds were ascertained by 1H NMR spectroscopy. Compounds 1a and 1b accounted for 60 % and dimethylarsinic acid for 5% of the water-soluble arsenic.
    Additional Material: 4 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 6 (1992), S. 343-349 
    ISSN: 0268-2605
    Keywords: HPLCICP MS ; arsenic speciation ; arsenobetaine ; arsenic-containing ribofuranosides ; tetramethylarsonium ; certified reference material ; bivalve molluscs ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Water-soluble arsenic compounds were extracted with methanol/water (1:1, v/v) from various species of bivalves and also from certified reference materials (NIES No. 6, mussel tissue, and NBS 1566, oyster tissue). The extracts were analyzed with a high-performance liquid chromatograph combined with an inductively coupled argon plasma mass spectrometer serving as an arsenic-specific detector. A certified reference material (NIES No. 6) was used to check the reproducibility of the analysis. The relative standard deviations (RSDs) of the peak area of major arsenic compounds among repeated measurements (n = 6) on the same extrct were less than 3.3%, indicating good reproducibility of the technique. The RSDs of some peaks among measurements of independent extracts, on the other hand, were more than 10%, possibly reflecting the heterogeneity of the sample in terms of the chemical species under the present experimental conditions. In many of the samples analyzed in the present study, two arsenic-containing ribofuranosides were detected in addition to arsenobetaine. A compound bearing a glycerophosphoryl glycerol moiety was dominant in such cases. Interestingly, a bivalve living in an estuary (Corbicula japonica) did not contain a detectable amount of arsenobetaine though it had arsenic-containing ribofuranosides. The distribution of arsenic species in the various parts of a clam (Meretrix lusoria) and a mussel (Mytilus coruscum) was also analyzed.
    Additional Material: 3 Ill.
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  • 9
    ISSN: 0170-2041
    Keywords: Lasiol ; Lavandulyl skeleton ; Terpenes ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Both enantiomers of lasiol, erythro-2,3,6-trimethyl-5-hepten-1-ol (1), were synthesized in 6 steps from the enantiomers of 3-methyl-4-butanolide (2).
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  • 10
    Publication Date: 1997-10-06
    Description: Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene. With the use of a conditional gene targeting system, a mouse model of FAP was created that circumvents the embryonic lethality of Apc deficiency and directs Apc inactivation specifically to the colorectal epithelium. loxP sites were inserted into the introns around Apc exon 14, and the resultant mutant allele (Apc580S) was introduced into the mouse germline. Mice homozygous for Apc580S were normal; however, upon infection of the colorectal region with an adenovirus encoding the Cre recombinase, the mice developed adenomas within 4 weeks. The adenomas showed deletion of Apc exon 14, indicating that the loss of Apc function was caused by Cre-loxP-mediated recombination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shibata, H -- Toyama, K -- Shioya, H -- Ito, M -- Hirota, M -- Hasegawa, S -- Matsumoto, H -- Takano, H -- Akiyama, T -- Toyoshima, K -- Kanamaru, R -- Kanegae, Y -- Saito, I -- Nakamura, Y -- Shiba, K -- Noda, T -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):120-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Cancer Institute, Toshima-ku, Tokyo 170, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311916" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli/*genetics ; Adenomatous Polyposis Coli Protein ; Adenoviridae/genetics ; Animals ; Colon/metabolism ; Cytoskeletal Proteins/biosynthesis ; Disease Models, Animal ; Exons ; Female ; Frameshift Mutation ; Gene Deletion ; *Gene Targeting ; *Genes, APC ; Genetic Vectors ; Germ-Line Mutation ; Homozygote ; Integrases/genetics/metabolism ; Introns ; Male ; Mice ; Mice, Inbred C57BL ; Recombination, Genetic ; *Viral Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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