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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnold, Kathryn E -- Owens, Ian P F -- Marshall, N Justin -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK. K.Arnold@bio.gla.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778040" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; *Feathers ; Female ; *Fluorescence ; Male ; Parrots/*physiology ; Pigments, Biological/*physiology ; *Sexual Behavior, Animal ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1995-01-27
    Description: Positron emission tomography was used to evaluate the regional distribution of cerebral glucose metabolism in 61 healthy adults at rest. Although the profile of metabolic activity was similar for men and women, some sex differences and hemispheric asymmetries were detectable. Men had relatively higher metabolism than women in temporal-limbic regions and cerebellum and relatively lower metabolism in cingulate regions. In both sexes, metabolism was relatively higher in left association cortices and the cingulate region and in right ventro-temporal limbic regions and their projections. These results are consistent with the hypothesis that differences in cognitive and emotional processing have biological substrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gur, R C -- Mozley, L H -- Mozley, P D -- Resnick, S M -- Karp, J S -- Alavi, A -- Arnold, S E -- Gur, R E -- MH-42191/MH/NIMH NIH HHS/ -- MH-43880/MH/NIMH NIH HHS/ -- MH-48539/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):528-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824953" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Basal Ganglia/metabolism ; Brain/*metabolism/radionuclide imaging ; Brain Stem/metabolism ; Cerebellum/metabolism ; Female ; Functional Laterality ; Glucose/*metabolism ; Gyrus Cinguli/metabolism ; Humans ; Limbic System/metabolism ; Male ; Occipital Lobe/metabolism ; Sex Characteristics ; Temporal Lobe/metabolism ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1986-09-19
    Description: WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 beta-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, T J -- Kremer, M J -- Luo, M -- Vriend, G -- Arnold, E -- Kamer, G -- Rossmann, M G -- McKinlay, M A -- Diana, G D -- Otto, M J -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1286-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3018924" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/metabolism/*pharmacology ; Binding Sites ; Chemical Phenomena ; Chemistry ; Humans ; Isoxazoles/metabolism/pharmacology ; Poliovirus/drug effects/metabolism ; Rhinovirus/*drug effects/metabolism ; X-Ray Diffraction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Reactions of D-Glucuronic Acid, XV Facile Syntheses of 5-Deoxy-hexofuranurono-6,3-lactonesDerivatives of 5-deoxy-D-xylo-hexofuranurono-6,3-lactone, an α-deoxylactone derived from a carbohydrate, were synthesized by three independent routes in which a combination of the reagents dichlorotriphenylphosphorane/triphenylphosphane provided a very facile access to such compounds.
    Notes: Derivate des 5-Desoxy-D-xylo-hexofuranurono-6,3-lactons, eines α-Desoxylactons der Kohlenhydratreihe, wurden auf drei verschiedenen Wegen synthetisiert, wobei die Reagenzkombination Dichlortriphenylphosphoran/Triphenylphosphan die Gewinnung solcher Verbindungen auf sehr einfache Weise erlaubte.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1985 (1985), S. 644-649 
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical Modification of Kanamycin A. - Derivatives Containing a 4,5-Double Bond in the Kanosamine PartOxidation of the primary alcohol group in the kanamycin A derivative 2b with simultaneous β-elimination gave the α,β-unsaturated aldehyde 3a of which the derivatives 3b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4 ‚-deoxy-5‘-epi-kanamycin A derivatives.
    Additional Material: 1 Tab.
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 108 (1996), S. 2054-2056 
    ISSN: 0044-8249
    Keywords: Enzyminhibitoren ; Fluorzucker ; Glycosidasen ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0170-2041
    Keywords: D-Glucofuranurono-6,3-lactone ; Reformatsky reaction ; 7-Deoxyoctoses ; Castanospermine ; Glycosidase inhibitors ; Carbohydrates ; Enzymes ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis of (+)-Castanospermine and 1-Epicastanospermine from D-Glucofuranurono-6,3-lactone by Reformatsky ReactionStarting from 5-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-α-D-gluco- (2a) or -β-L-idofuranurono-6,3-lactone (2b), 7-deoxyoctofuranose derivatives 5a, 5b, 7a and 7b have been synthesized by chain extension at C-6 by Reformatsky reaction followed by reduction with calcium borohydride. The respective configuration of the products was determined by transformation into the known 7,8-dideoxyoctofuranoses 5o, 5p, 7k and 7l. From the mixture of 7a and 7b, formed in a proportion of approximately 4:1, the glycosidase inhibitors (+)-castanospermine (1a) and 1-epicastanospermine (1b) have been prepared in 8 and 9 simple steps, respectively, in overall yields of 33.4 and 9.5%.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 35 (1996), S. 1926-1928 
    ISSN: 0570-0833
    Keywords: enzyme inhibitors ; fluoro sugars ; glycosidases ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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