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  • 1
    Electronic Resource
    Electronic Resource
    Direct visualization of particle velocity distribution by pseudostereoscopic viewing of time-lapsed sequential images: Application to fast axonal transport (1984)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 4 (1984), S. 231-239 
    Details
    ISSN: 0886-1544
    Keywords: pseudostereoscopy ; particle speed distribution ; velocity distribution ; fast axonal transport ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We describe a simple method for direct visualization of the velocity distribution of particles moving against an immobile background. The technique involves pseudostereoscopic viewing of image pairs separated by an appropriate time interval in a sequential recording of the subject. Under these conditions, the positive or negative parallax arising from particle motion results in the binocular image of a particle being perceived as raised or lowered relative to an immobile background plane depending on its direction of movement, and with the degree of perceived elevation being proportional to its speed. In effect, the binocular optic axis becomes a velocity (speed) axis under these conditions. The technique is illustrated with examples of image pair sequences showing fast axonal transport in lobster and squid axons using video-enhanced differential interference contrast microscopy. However, the pseudostereoscopic method is quite generally applicable to both microscopic and macroscopic time-dependent phenomena. Particle speeds can be quantitated using standard procedures for measuring frame-to-frame particle displacements, or alternatively, by determination of parallax using stereogrammatic methods. It should be also readily adaptable for on-line monitoring of particle velocity distribution, particularly in video systems where frame buffers can be utilized to extract and present serial image pairs having any desired time separation from video-taped sequences.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970040402
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  • 2
    Electronic Resource
    Electronic Resource
    Use of isotopically chiral [4′-13C]famciclovir and 13C NMR to identify the chiral monoacetylated intermediates in the conversion of famciclovir to penciclovir by human intestinal wall extract (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 577-582 
    Details
    ISSN: 0899-0042
    Keywords: Chiral stereospecificity ; esterase ; metabolism ; human tissue ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Famciclovir is the oral form of the potent antiherpesvirus agent, penciclovir. Hydrolysis of one of the acetyl ester groups of famciclovir creates a chiral centre leading to the possible formation of (R)- and (S)-enantiomers. During its conversion to penciclovir, famciclovir forms two chiral metabolites, namely monoacetyl-6-deoxy-penciclovir and monoacetyl-penciclovir. The absolute configuration and stereospecificity of the monoacetyl metabolites of famciclovir, produced in human intestinal wall extract, were determined using isotopically chiral famciclovir and 13C NMR spectroscopy of the isolated metabolites. 13C NMR showed that the esterase(s), in human intestinal wall extract, hydrolysed the acetyl group preferentially from the pro-(S)-acetoxymethyl group of famciclovir. The specificity of esterase action in forming monoacetyl-6-deoxy-penciclovir and monoacetyl-penciclovir was about 77 and 72%, respectively. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530050803
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  • 3
    Electronic Resource
    Electronic Resource
    Use of isotopically chiral [4′-13C]penciclovir and 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1- and HSV-2-infected cells and by HSV-1-encoded thymidine kinase (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 583-588 
    Details
    ISSN: 0899-0042
    Keywords: chiral stereospecificity ; phosphorylation ; MRC-5 cells ; herpesvirus ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Penciclovir is a potent antiherpesvirus agent which is highly selective due to its phosphorylation only in virus infected cells. Phosphorylation of one of the hydroxymethyl groups of penciclovir (PCV) creates a chiral centre leading to the possible formation of (R)- and (S)-enantiomers. The absolute configuration and stereospecificity of the PCV-phosphates produced in cells infected with herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2), as well as by HSV-1-encoded thymidine kinase, were determined using isotopically chiral [4′-13C]PCV precursors and 13C NMR spectroscopy of the isolated metabolites. The absolute configuration of penciclovir-triphosphate (PCV-TP) produced in HSV-1-infected cells was shown to be S with an enantiomeric purity of greater than 95%. However, in contrast to HSV-1-infected cells in which none of the (R) enantiomer was detected, about 10% of (R)-PCV-TP was produced in HSV-2-infected cells. Phosphorylation of PCV by HSV-1-encoded thymidine kinase was found to give 75% (S)- and 25% (R)-PCV-monophosphate. The proportion of the (S)-isomer appears to be amplified in the subsequent phosphorylations leading to the triphosphate. © 1993 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530050804
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  • 4
    Electronic Resource
    Electronic Resource
    Chemistry and technology of cyanate ester resins, I. Hamerton, ed. Blackie A&P, London (1994), ISBN 0-7514-0044-0, 357 pp., £69.00 (1995)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 6 (1995), S. 745-745 
    Details
    ISSN: 1042-7147
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1995.220061205
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  • 5
    Electronic Resource
    Electronic Resource
    Cyclic polymers: past, present and future (1994)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 5 (1994), S. 473-478 
    Details
    ISSN: 1042-7147
    Keywords: Cyclic polymer ; Poly(dimethylsiloxane) ; Polymer supported reactions ; Polymeric catenanes ; Topological polymer chemistry ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Methods for characterising cyclic polymers are illustrated by reference first to dilute solution methods for cyclic poly(dimethylsiloxane) (PDMS) and then to the entrapment of cyclic polymers in networks. Preparative routes to cyclic polymers are then reviewed, including ring-chain equilibration reactions, coupling and condensation reactions and new methods using polymer-supported reagents. Some of the properties of cyclic PDMS are discussed, including differences between ring and chain polymer properties such as their melt viscosities and glass transition temperatures. Methods for preparing the first polymeric catenanes are described, using polymer-supported reagents. Future directions for cyclic polymer chemistry are indicated, including topological polymer chemistry.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1994.220050902
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of stress and vapor exposure before and during aging on enthalpy relaxation of poly(vinyl chloride) (1984)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 24 (1984), S. 1123-1129 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Enthalpy relaxations in glassy poly(vinyl chloride) following varied pre-aging treatments and under varied aging conditions have been compared through observations of sub-Tg endothermal DSC (differential scanning calorimetry) aging peaks. The extent of enthalpy relaxation for a fixed time and temperature of aging is progressively enhanced by the imposition and release of increasing mechanical stress before aging. The same effect is produced by sorption and desorption of increasing amounts of CO2 or CH3Cl vapor before aging. In contrast, the continued application of mechanical stress, or the presence of vapor, during the aging period suppresses enthalpy relaxation. The extent of suppression increases with increasing vapor pressure and solubility or increasing stress. These effects are interpreted as consequences of an increase in the enthalpy of the polymer under mechanical or sorptive stress and an enthalpy relaxation following the release of this stress. In addition to these effects on the DSC endotherm, a pronounced exotherm between the aging peak and Tg is observed for samples which have undergone shear yielding or orientation either before or during aging. This exotherm may be the result of release of stored strain energy during the DSC scan.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760241408
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  • 7
    Electronic Resource
    Electronic Resource
    A microscopical study of changes due to functional activity in nerve cells (1892)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 7 (1892), S. 95-168 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1050070202
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  • 8
    Electronic Resource
    Electronic Resource
    The anatomy and histology of the alimentary tract of the grasshopper, melanoplus differentialis ThomasContribution no. 7 from the laboratories of the Department of Biology, Temple University. (1936)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 59 (1936), S. 423-439 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: This investigation is intended to be the first of a contemplated series to study correlation of diet with morphological change. The material here reported is from grasshoppers on satisfactory diets. The gross anatomy shows a typically acridine arrangement. Fixation with B3 and staining with haematoxylin and eosin shows that peritoneum, muscle and chitin in different areas vary only in arrangement and relative development. The epithelial cells of the various regions differ in structure as well. Modifications of the cytoplasmic elements of these cells are correlated with cellular activity. The epithelial cells of the mid-gut and its six bi-lobed gastric caeca, and of the six rectal glands have a striated border of separate filaments which are cilia-like in appearance but devoid of motion. The caeca are most active in gastric secretion, which is merocrine or holocrine according to conditions. Essentially different granules and vacuoles are secreted, and extruded by rupture of the cells; which are replaced from nidi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1050590302
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  • 9
    Electronic Resource
    Electronic Resource
    A microscopical study of the nerve cell during electrical stimulation (1894)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 9 (1894), S. 449-463 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1050090306
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  • 10
    Electronic Resource
    Electronic Resource
    The anatomy and histology of the alimentary tract of locusta migratoria L. (orthoptera: Acrididae) (1939)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 64 (1939), S. 375-399 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1050640302
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