ISSN:
1434-193X
Schlagwort(e):
Asymmetric synthesis
;
Chiral induction
;
Cyanohydrin
;
Cycloaddition
;
Nitrone
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The intramolecular 1,3-dipolar cycloaddition of ω-un-saturated chiral nitrones is described. Starting materials for this reaction are O-protected chiral cyanohydrins, prepared by an R-oxynitrilase catalyzed asymmetric addition of hydrogen cyanide to ω-unsaturated aldehydes. Intramolecular cycloaddition, followed by reductive opening of the isoxazolidine ring, produced five- and seven-membered ring compounds with chiral hydroxy and amine functionalities of high enantiomeric purity in excellent yield.
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
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