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  • Chemically modified electrode  (1)
  • enzymatic resolution  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of microbiology and biotechnology 15 (1999), S. 631-633 
    ISSN: 1573-0972
    Keywords: Enantioselectivity ; 3-(3-indolyl)butyric acid ; enzymatic resolution ; indolmycin ; lipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Both enantiomers of 3-(3-indolyl)butyric acid, a key intermediate of indolmycin, were successfully prepared by lipase-catalysed enantioselective hydrolysis. Of the enzymes examined, Pseudomonas fluorescens lipase (lipase AK) showed the best enantioselectivity and highest reactivity for the hydrolysis of (±)-trifluoroethyl 3-(3-indolyl)butyrate. Under optimal conditions, optical resolution was completed in one enzyme-catalysed step, the S-acid and unreacted R-ester being obtained in high optical purity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Electroanalysis 9 (1997), S. 1030-1032 
    ISSN: 1040-0397
    Keywords: Chemically modified electrode ; Myoglobin ; Captopril ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A silver electrode coated with captopril, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline, was prepared by covalent bonding method. The modified electrode was long-lived and stable. Experimental results revealed that myoglobin (Myb) could exhibit good voltammetric response at the modified electrode. Square wave voltammetric measurements of Myb with the modified electrode gave a linear relationship between the anodic peak current and the protein concentration in the range of 4 × 10-6 -5 × 10-5 mol/L. The relative standard deviation is 5 % for 6 successive determinations in 2 × 10-5 mol/L Myb.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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