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The suitability of some preservatives in chloroquine phosphate syrup (1988)

Doorne, H. ; Wieringa, N. F. ; Bosch, E. H. ; [et al.]

Springer

Pharmacy world & science 10 (1988), S. 170-172

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ISSN: 1573-739X

Keywords: Chloroquine ; Citric acid ; Drug stability ; Parabens ; Preservatives, pharmaceutical ; Sorbic acid ; Syrup

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01959426

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Novel method for noncontact measurement of particle temperatures (1995)

Wagenaar, B. M. ; Meijer, R. ; Kuipers, J. A. M. ; [et al.]

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 41 (1995), S. 773-782

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: A nonintrusive temperature measurement technique is developed for noncontact measurement of the temperature of single particles with 〈 200 μm dia. It is based on the temperature dependence of the fluorescence spectrum resulting from irradiation of a certain phosphor mixture with UV light by applying a mixture of two phosphors with fluorescence colors (blue and green) and a color shift from green to blue (with temperature increase from 20 to 280°C). An experimental setup is described for temperature measurement of particles based on the fluorescence color, together with the calibration of this system. The fluoroptic technique is applied to measure the temperature decrease of hot particles flowing down a cold chute. The measurements agree very well with thermocouple measurements. This novel technique can be applied to nonintrusive measurement of particle temperatures in (dense) multiparticle systems as encountered in packed and fluidized beds.

Additional Material: 15 Ill.