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  • Chemistry  (3)
  • Chemical Engineering  (2)
  • phase II  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A phase II trial of oral 4′ demethoxydaunorubicin (DMDR) in inoperable non small cell lung cancer (1988)
    Springer
    Investigational new drugs 6 (1988), S. 219-221 
    Details
    ISSN: 1573-0646
    Keywords: 4′demethoxydaunorubicin ; oral ; non small cell lung cancer ; phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 4′ Demethoxydaunorubicin, an orally active daunorubicin analogue, was administered to 22 patients with inoperable non small cell lung cancer (NSCLC). Patients were stratified into good and poor risk categories and received doses of 45 mg/m2 and 40 mg/m2 respectively at 28 day intervals. All 22 patients were evaluable for response: No tumour responses occurred. Therapy was well tolerated. Mild gastrointestinal toxicity occurred in 41% of patients. Leucopenia with a wcc 〈 3 × 109/L occurred in 33% of patients and thrombocytopenia 〈 100 × 109/L in 9%. Severe marrow toxicity was rare and there appeared to be no difference in terms of toxicity between the different dose levels. DMDR appears to have no useful clinical activity in NSCLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175402
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  • 2
    Electronic Resource
    Electronic Resource
    DSC and FTIR characterization of biodegradation of polyethylene (1992)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 438-442 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Aspergillus niger, a fungus, was used in the degradation of commercially available thermoplastic polyethylene films. Quantitative calorimetric measurements performed on as-received, abiotic, and biotic treated polyethylene samples, revealed that the amorphocity of the sample decreases during biodegradation. In addition, it was found that the external substrates (sucrose) in the growth medium influenced the biodegradation process of polyethylene. Furthermore, the crystallinity data on different biotreated samples indicated that the adapted microorganisms were able to metabolize a small portion of polyethylene. The significance of the Fourier transform infrared (FTIR) results of polyethylene samples have been discussed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760320609
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  • 3
    Electronic Resource
    Electronic Resource
    Authors' Rebuttal (1993)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 33 (1993), S. 1509-1510 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760332212
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of charge density and steric factor of aminated chloromethyl polystyrene homologs in bilirubin adsorption (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 42 (1991), S. 2483-2488 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Bilirubin, a bile pigment, was studied for its extent of adsorption on substituted aminechloromethyl polystyrene by UV spectrophotometry. By performing simple displacement reactions on chloromethyl polystyrene with secondary and tertiary amines, the amount of charge density and steric factor on substituted nitrogen atom have been varied. Adsorption isotherms of bilirubin at 0°C by different amine-chloromethyl polystyrene homologs suggest the existence of electrostatic interaction of polymeric resin with bilirubin moiety. Results of adsorption of bilirubin to polymeric resin have shown that the extent of adsorption of bilirubin depends on the unit charge, and on the structure of the substituted amine-chloromethyl polystyrene. The effects of porosity of resin on bilirubin adsorption have also been discussed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1991.070420913
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