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  • Cerebral  (1)
  • Quenching  (1)
  • 1
    Electronic Resource
    Electronic Resource
    System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination (1988)
    Springer
    Medical & biological engineering & computing 26 (1988), S. 289-294 
    Details
    ISSN: 1741-0444
    Keywords: Cerebral ; Cytochrome aa3 ; Haemoglobin ; Near infra-red ; Oxygenation ; Spectroscopy ; Transillumination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The technique of near-infra-red spectroscopy allows safe continuous monitoring of changes in blood and tissue oxygenation on an intact organ. This is made possible by observing spectral changes in the tissues caused by oxygenated haemoglobin [HbO2], deoxygenated haemoglobin [Hb] and cytochrome aa3 [Cyt aa3]. The paper describes the design and performance of an instrument that has been developed to apply this technique to the monitoring of the brain in newborn infants. The instrument monitors optical transmission changes across a newborn infant's brain at four wavelengths. A standard deviation in error of 1 per cent (0·01 optical density OD) is achieved on measurements of transmission changes at 20s intervals. This performance is obtained at a mean attenuation of 10 OD, the approximate attenuation across a term infant's head. Long-term monitoring is possible as instrumental drift is less than 0·004 OD per hour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447083
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  • 2
    Electronic Resource
    Electronic Resource
    Optical oxygen sensor based on phosphorescence lifetime quenching and employing a polymer immobilised metalloporphyrin probe (1993)
    Springer
    Medical & biological engineering & computing 31 (1993), S. 11-21 
    Details
    ISSN: 1741-0444
    Keywords: Lifetime ; Metalloporphyrin ; Oxygen ; Phosphorescence ; Polymer ; Quenching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A gaseous oxygen sensor is described based on the measurement of phosphorescence lifetime of the dye palladium coproporphyrin, immobilised in a range of membrane materials including polyvinyl chloride, polymethylmethacrylate, polystyrene and silicone rubber. The lifetime of the dye in these materials is described, measured using a simple system consisting of a pulsed xenon flash lamp light source and a PC-based data acquisition system. The linearity of the sensing membranes over the 0–100 per cent oxygen range is presented together with data on temperature sensitivity, the effects of CO2, N2O, H2O and halothane, and the effects of ageing over a 90 day period. The sensors based upon polystyrene immobilised dye appear to provide the optimum characteristics for a gaseous oxygen sensor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446880
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