ISSN:
0170-2041
Keywords:
Cephems, 3-alkenyl-
;
Cephalosporins
;
Wittig reactions
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Several novel cephalosporins 4-19 having substituted vinyl functionalities at C-3 were synthesized. The title compounds were prepared by a short and simple reaction sequence starting from protected 7-aminocephalosporanic acid derivatives 1-3 and involving cleavage with iodotrimethylsilane, phosphonium salt formation, and subsequent Wittig reaction. The effect of the substituents are also discussed.
Additional Material:
4 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1992199201148
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