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  • 1
    Electronic Resource
    Electronic Resource
    Preblastoderm mosaics of mutants of the bithorax-complex (1982)
    Springer
    Development genes and evolution 191 (1982), S. 331-334 
    Details
    ISSN: 1432-041X
    Keywords: Genetic mosaics ; Cell autonomy ; Cell affinities ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary InDrosophila melanogaster, segmental specification takes place in groups of cells around the blastoderm stage. This segmental specification requires the function of the genes of the bithorax-complex. We have studied preblastoderm mosaics (gynandromorphs) of mutant (bx 3,pbx, Ubx, Ubx 80) and wildtype (heterozygotes for these alleles) cells. The results show a total cell autonomy in the differentiation of both wildtype and homoeotially transformed cells. However, several unexpected phenotypes were found. They are discussed in terms of the function of the bithorax genes and early interactions between mutant and wildtype territories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848493
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic interactions between the Polycomb locus and the Antennapedia and Bithorax complexes of Drosophila (1986)
    Springer
    Development genes and evolution 195 (1986), S. 417-432 
    Details
    ISSN: 1432-041X
    Keywords: Gene regulation ; Developmental pathways ; Antennapedia and Bithorax complexes in Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have studied the embryonic and adult phenotypes of genetic combinations between Polycomb (Pc), Regulator of bithorax (Rg-bx) and the genes of the Bithorax complex (BX-C) and the Antennapedia complex (ANT-C). The products of Pc and Rg-bx genes act antagonistically, their mutant combinations leading to the ectopic expression of genes of the BX-C and ANT-C. The genetic analysis of the Pc locus suggests it is a complex gene. Pc+ products behave as members of a “regulatory set” that negatively control the expression of BX-C and ANT-C genes. Genetic combinations between different doses of Pc, Rg-bx and the genes of the BX-C and ANT-C have phenotypes which may be interpreted as resulting from ectopic derepression of posterior selector genes repressing selector genes of anterior segments. The transformation phenotypes of certain genetic combinations differ in embryos and adults. A model of regulation of the BX-C and the ANT-C genes during the imaginal cell proliferation is presented, in which the specification state is maintained by self-activation of a given selector gene and down modulation of other selector genes in the same cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375746
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    Paper (German National Licenses)
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