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  • 1
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    Evidence for cardiomyocyte renewal in humans (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-04
    Description: It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991140/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991140/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, Olaf -- Bhardwaj, Ratan D -- Bernard, Samuel -- Zdunek, Sofia -- Barnabe-Heider, Fanie -- Walsh, Stuart -- Zupicich, Joel -- Alkass, Kanar -- Buchholz, Bruce A -- Druid, Henrik -- Jovinge, Stefan -- Frisen, Jonas -- P41 GM103483/GM/NIGMS NIH HHS/ -- P41 RR013461/RR/NCRR NIH HHS/ -- P41 RR013461-11/RR/NCRR NIH HHS/ -- RR13461/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 3;324(5923):98-102. doi: 10.1126/science.1164680.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342590" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aging ; Carbon Radioisotopes/analysis ; Cell Count ; Cell Nucleus/chemistry ; Cell Nucleus Division ; Cell Proliferation ; Cell Separation ; DNA/*biosynthesis ; Echocardiography, Doppler, Color ; Humans ; Middle Aged ; Models, Cardiovascular ; Myocytes, Cardiac/*cytology/metabolism ; Nuclear Weapons ; Polyploidy ; Radiometric Dating ; Stem Cells/cytology ; Troponin I/analysis ; Troponin T/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A pericyte origin of spinal cord scar tissue (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-09
    Description: There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goritz, Christian -- Dias, David O -- Tomilin, Nikolay -- Barbacid, Mariano -- Shupliakov, Oleg -- Frisen, Jonas -- 250297/European Research Council/International -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):238-42. doi: 10.1126/science.1203165.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21737741" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/pathology/physiology ; Blood Vessels/pathology ; Cell Count ; Cell Proliferation ; Cicatrix/*pathology ; Fibrosis ; Mice ; Mice, Transgenic ; Pericytes/*pathology/physiology ; Spinal Cord/blood supply/*pathology ; Spinal Cord Injuries/*pathology ; Stromal Cells/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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