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    Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: During the immediate-early response of mammalian cells to mitogens, histone H3 is rapidly and transiently phosphorylated by one or more unidentified kinases. Rsk-2, a member of the pp90rsk family of kinases implicated in growth control, was required for epidermal growth factor (EGF)-stimulated phosphorylation of H3. RSK-2 mutations in humans are linked to Coffin-Lowry syndrome (CLS). Fibroblasts derived from a CLS patient failed to exhibit EGF-stimulated phosphorylation of H3, although H3 was phosphorylated during mitosis. Introduction of the wild-type RSK-2 gene restored EGF-stimulated phosphorylation of H3 in CLS cells. In addition, disruption of the RSK-2 gene by homologous recombination in murine embryonic stem cells abolished EGF-stimulated phosphorylation of H3. H3 appears to be a direct or indirect target of Rsk-2, suggesting that chromatin remodeling might contribute to mitogen-activated protein kinase-regulated gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sassone-Corsi, P -- Mizzen, C A -- Cheung, P -- Crosio, C -- Monaco, L -- Jacquot, S -- Hanauer, A -- Allis, C D -- GM40922/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Aug 6;285(5429):886-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, B. P. 163, 67404 Illkirch-Strasbourg, France. paolosc@igbmc.u-strasbg.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10436156" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Abnormalities, Multiple/genetics/metabolism ; Animals ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cell Line, Transformed ; Cell Nucleus/metabolism ; Cells, Cultured ; Epidermal Growth Factor/*pharmacology ; Gene Expression Regulation ; Gene Targeting ; Histones/*metabolism ; Humans ; Mice ; Mitosis ; Mutation ; Phosphorylation ; Ribosomal Protein S6 Kinases/genetics/*metabolism ; Signal Transduction ; Stem Cells/cytology/metabolism ; Syndrome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    CREM-dependent transcription in male germ cells controlled by a kinesin (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: ACT is a LIM-only protein expressed exclusively in round spermatids, where it cooperates with transcriptional activator CREM in regulating various postmeiotic genes. Targeted inactivation of CREM leads to a complete block of mouse spermiogenesis. We sought to identify the regulatory steps controlling the functional interplay between CREM and ACT. We found that ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells. The ACT-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of ACT. Sensitivity to leptomycin B indicates that KIF17b can be actively exported from the nucleus through the Crm1 receptor. Thus, a kinesin directly controls the activity of a transcriptional coactivator by a tight regulation of its intracellular localization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macho, Betina -- Brancorsini, Stefano -- Fimia, Gian Maria -- Setou, Mitsutoshi -- Hirokawa, Nobutaka -- Sassone-Corsi, Paolo -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2388-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire, B. P. 10142, 67404 Illkirch, Strasbourg, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493914" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Amino Acid Sequence ; Animals ; COS Cells ; Cell Nucleus/metabolism ; Cyclic AMP Response Element Modulator ; Cytoplasm/metabolism ; DNA-Binding Proteins/metabolism ; Fatty Acids, Unsaturated/pharmacology ; Gene Expression Regulation, Developmental ; Karyopherins/metabolism ; Kinesin/chemistry/genetics/*metabolism ; LIM Domain Proteins ; Male ; Mice ; Molecular Motor Proteins/chemistry/genetics/*metabolism ; Molecular Sequence Data ; Promoter Regions, Genetic ; Protein Isoforms/chemistry/genetics/metabolism ; *Receptors, Cytoplasmic and Nuclear ; *Repressor Proteins ; Spermatids/*metabolism ; *Spermatogenesis ; Testis/metabolism ; Transcription Factors/genetics/*metabolism ; *Transcription, Genetic ; Transcriptional Activation ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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