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  • 1
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    Generation of pluripotent stem cells from adult human testis (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-10-14
    Description: Human primordial germ cells and mouse neonatal and adult germline stem cells are pluripotent and show similar properties to embryonic stem cells. Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice. The human adult germline stem cells differentiated into various types of somatic cells of all three germ layers when grown under conditions used to induce the differentiation of human embryonic stem cells. We conclude that the generation of human adult germline stem cells from testicular biopsies may provide simple and non-controversial access to individual cell-based therapy without the ethical and immunological problems associated with human embryonic stem cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conrad, Sabine -- Renninger, Markus -- Hennenlotter, Jorg -- Wiesner, Tina -- Just, Lothar -- Bonin, Michael -- Aicher, Wilhelm -- Buhring, Hans-Jorg -- Mattheus, Ulrich -- Mack, Andreas -- Wagner, Hans-Joachim -- Minger, Stephen -- Matzkies, Matthias -- Reppel, Michael -- Hescheler, Jurgen -- Sievert, Karl-Dietrich -- Stenzl, Arnulf -- Skutella, Thomas -- England -- Nature. 2008 Nov 20;456(7220):344-9. doi: 10.1038/nature07404. Epub 2008 Oct 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Anatomy, Department of Experimental Embryology, Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18849962" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Biomarkers/metabolism ; Cell Culture Techniques ; Cell Differentiation ; Cell Line ; Cell Lineage ; Cells, Cultured ; Embryonic Stem Cells/cytology/metabolism ; Epigenesis, Genetic ; Gene Expression Profiling ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Pluripotent Stem Cells/*cytology/metabolism ; Spermatogonia/cytology/ultrastructure ; Teratoma/pathology ; Testis/*cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Steroid control of longevity in Drosophila melanogaster (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-03-01
    Description: Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon, Anne F -- Shih, Cindy -- Mack, Antha -- Benzer, Seymour -- AG16630/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1407-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology 156-29, California Institute of Technology, 1201 California Boulevard, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610309" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Weight ; Crosses, Genetic ; Drosophila melanogaster/genetics/growth & development/*physiology ; Ecdysone/biosynthesis/*physiology ; Ecdysterone/administration & dosage/pharmacology ; Female ; Fertility ; Genes, Insect ; Ligands ; *Longevity ; Male ; Mutation ; Oxidative Stress ; Phototropism ; Receptors, Steroid/genetics/*physiology ; Starvation ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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