Publication Date:
2003-03-22
Description:
T lymphocytes are generated in the thymus, where developing thymocytes must accept one of two fates: They either differentiate or they die. These fates are chiefly determined by signals that originate from the T cell receptor (TCR), a single receptor complex with a remarkable capacity to decide between distinct cell fates. This review explores TCR signaling in thymocytes and focuses on the kinetic aspects of ligand binding, coreceptor involvement, protein phosphorylation, and mitogen-activated protein kinase (MAPK) activation. Understanding the logic of TCR signaling may eventually explain how thymocytes and T cells distinguish self from nonself, a phenomenon that has fascinated immunologists for 50 years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Werlen, Guy -- Hausmann, Barbara -- Naeher, Dieter -- Palmer, Ed -- New York, N.Y. -- Science. 2003 Mar 21;299(5614):1859-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital-Basel, CH-4031 Basel, Switzerland. guy.werlen@unibas.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12649474" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptor Proteins, Signal Transducing
;
Animals
;
Antigens/immunology
;
Antigens, CD/immunology/metabolism
;
*Apoptosis
;
Carrier Proteins/metabolism
;
Cell Differentiation
;
Cell Division
;
Enzyme Activation
;
Humans
;
Ligands
;
MAP Kinase Signaling System
;
Major Histocompatibility Complex/immunology
;
*Membrane Proteins
;
Mitogen-Activated Protein Kinases/metabolism
;
Phosphoproteins/metabolism
;
Receptors, Antigen, T-Cell, alpha-beta/chemistry/immunology/*physiology
;
Selection, Genetic
;
Self Tolerance
;
*Signal Transduction
;
T-Lymphocytes/immunology/*physiology
;
Thymus Gland/*cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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