Publication Date:
2013-10-26
Description:
The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C(CCS52A2) ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heyman, Jefri -- Cools, Toon -- Vandenbussche, Filip -- Heyndrickx, Ken S -- Van Leene, Jelle -- Vercauteren, Ilse -- Vanderauwera, Sandy -- Vandepoele, Klaas -- De Jaeger, Geert -- Van Der Straeten, Dominique -- De Veylder, Lieven -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):860-3. doi: 10.1126/science.1240667. Epub 2013 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Systems Biology, VIB, B-9052 Gent, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24158907" target="_blank"〉PubMed〈/a〉
Keywords:
Anaphase-Promoting Complex-Cyclosome/metabolism
;
Arabidopsis/*cytology/*growth & development
;
Arabidopsis Proteins/genetics/*metabolism
;
Cell Cycle/genetics/physiology
;
Cell Cycle Proteins/metabolism
;
Cell Division/genetics/*physiology
;
Mitosis/genetics/physiology
;
Peptide Hormones/genetics/metabolism
;
Plant Roots/*cytology/*growth & development
;
Proteolysis
;
Signal Transduction
;
Stem Cell Niche
;
Stem Cells/*physiology
;
Transcription Factors/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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