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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archive of applied mechanics 66 (1996), S. 357-368 
    ISSN: 1432-0681
    Keywords: amplitude ; linear vibration ; excitation ; damping ; bound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary For reasons of safety and reliability, the maximum amplitudes of vibration responses must be taken into account in engineering. The exact maximum amplitudes are available from solving linear differential equations. However, for large scale systems, it requires too much computation time to be useful. Therefore, simple amplitude bounds are of great interest for engineers. Up to now, only for classically dampled linear systems, some approximate amplitude bounds were presented. In this paper, amplitude bounds of linear forced vibrations are presented for general dampled linear vibrating systems. For transient, harmonic and step excitations, the presented amplitude bounds show simple relations to the system parameters, and are easy to calculate. The advantage is the possibility to judge the level of vibrations, and to choose appropriate parameters at design. Compared with the approximate underestimating amplitude bounds available in literature, the presented amplitude bounds are overestimating the maximum amplitude and, therefore, can be safely applied to general damped vibrating systems.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archive of applied mechanics 66 (1996), S. 357-368 
    ISSN: 1432-0681
    Keywords: amplitude ; linear vibration ; excitation ; damping ; bound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary  For reasons of safety and reliability, the maximum amplitudes of vibration responses must be taken into account in engineering. The exact maximum amplitudes are available from solving linear differential equations. However, for large scale systems, it requires too much computation time to be useful. Therefore, simple amplitude bounds are of great interest for engineers. Up to now, only for classically damped linear systems, some approximate amplitude bounds were presented. In this paper, amplitude bounds of linear forced vibrations are presented for general damped linear vibrating systems. For transient, harmonic and step excitations, the presented amplitude bounds show simple relations to the system parameters, and are easy to calculate. The advantage is the possibility to judge the level of vibrations, and to choose appropriate parameters at design. Compared with the approximate underestimating amplitude bounds available in literature, the presented amplitude bounds are overestimating the maximum amplitude and, therefore, can be safely applied to general damped vibrating systems.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
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  • 3
    Publication Date: 2018-11-30
    Description: Although genomic instability, epigenetic abnormality, and gene expression dysregulation are hallmarks of colorectal cancer, these features have not been simultaneously analyzed at single-cell resolution. Using optimized single-cell multiomics sequencing together with multiregional sampling of the primary tumor and lymphatic and distant metastases, we developed insights beyond intratumoral heterogeneity. Genome-wide DNA methylation levels were relatively consistent within a single genetic sublineage. The genome-wide DNA demethylation patterns of cancer cells were consistent in all 10 patients whose DNA we sequenced. The cancer cells’ DNA demethylation degrees clearly correlated with the densities of the heterochromatin-associated histone modification H3K9me3 of normal tissue and those of repetitive element long interspersed nuclear element 1. Our work demonstrates the feasibility of reconstructing genetic lineages and tracing their epigenomic and transcriptomic dynamics with single-cell multiomics sequencing.
    Keywords: Cell Biology, Medicine, Diseases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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