Publication Date:
2001-09-22
Description:
SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peterson, E J -- Woods, M L -- Dmowski, S A -- Derimanov, G -- Jordan, M S -- Wu, J N -- Myung, P S -- Liu, Q H -- Pribila, J T -- Freedman, B D -- Shimizu, Y -- Koretzky, G A -- R01 AI060921/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2263-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Abramson Family Cancer Research Institute, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567141" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/metabolism
;
*Adaptor Proteins, Signal Transducing
;
Animals
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Antigens, CD/metabolism
;
Antigens, CD3/immunology
;
Antigens, Differentiation, T-Lymphocyte/metabolism
;
Carrier Proteins/genetics/*metabolism
;
Cell Adhesion
;
Cell Membrane/metabolism
;
Immunologic Capping
;
Intercellular Adhesion Molecule-1/metabolism
;
Interleukin-2/biosynthesis/pharmacology
;
Lectins, C-Type
;
Lymphocyte Activation
;
Lymphocyte Function-Associated Antigen-1/*physiology
;
Mice
;
Phosphatidylinositol 3-Kinases/metabolism
;
Phosphoproteins/genetics/*metabolism
;
Protein-Tyrosine Kinases/metabolism
;
Receptors, Antigen, T-Cell/*metabolism
;
Receptors, Interleukin-2/metabolism
;
Signal Transduction
;
T-Lymphocytes/immunology/metabolism/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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