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New radiological finding by magnetic resonance imaging examination of the brain in Coffin-Lowry syndrome (1998)

Kondoh, Tatsuro ; Matsumoto, Tadashi ; Ochi, Makoto ; [et al.]

Springer

Journal of human genetics 43 (1998), S. 59-61

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ISSN: 1435-232X

Keywords: Key words Coffin-Lowry syndrome ; Multiple perivascular space ; Magnetic resonance imaging (MRI) ; Mucopolysaccharidosis ; Perivascular leukomalacia

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract We used magnetic resonance imaging (MRI) to examine the brain of a typical Coffin-Lowry syndrome (CLS) patient. There were many small perivascular focal areas of hypointensity in the white matter on T1-weighted images, similar to those found in mucopolysaccharidosis or perivascu-lar leukomalacia. However, these changes could not seen in another patient we examined. Both patients showed normal urinary mucopolysaccharide patterns with chromatographic analysis. The cause of the MRI result is not known, but it could have a heterogeneous origin, and this result could represent an important indication defining one type of CLS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s100380050038

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Characterization of the membrane-associated GTPase activity: Effects of chemotactic factors and toxins (1989)

Pelz, Claudia ; Matsumoto, Tadashi ; Molski, Thaddeus F. P. ; [et al.]

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 39 (1989), S. 197-206

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ISSN: 0730-2312

Keywords: neutrophil ; GTPase ; fMet-Leu-Phe ; leukotriene ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Membranes prepared from rabbit neutrophils exhibit GTPase activity which can be stimulated by the chemotactic factor fMet-Leu-Phe. The maximum contribution of the ATPase activities to the basal and the fMet-Leu-Phe-stimulated GTPase activities are less than 20% and 9%, respectively. The basal GTPase activity has a Vmax = 34.2 ± 1.3 (pmol/mg protein, min) and a Km = 0.39 ± 0.03 μM; and the fMet-Leu-Phe-stimulated has a Vmax = 52.3 ± 2.5 (pmol/mg protein, min), and a Km = 0.29 ± 0.02 μM. The GTPase activity can be stimulated by fMet-Leu-Phe and leukotriene B4. Unlike these two chemotactic factors, concanavalin A does not stimulate this GTPase activity. In addition, the rise in intracellular concentration of free calcium produced by concanavalin A is not inhibited by pertussis toxin treatment. Both the basal and stimulated GTPase activities are affected by pertussis toxin, cholera toxin and N-ethylmaleimide.

Additional Material: 6 Ill.