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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-09-01
    Description: When hens are raised to sexual maturity from hatching with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] as their sole source of cholecalciferol (vitamin D3), fertile eggs appear to develop normally but fail to hatch. When hens receive a combination of 1,25(OH)2D3 and 24R,25-dihydroxyvitamin D3 [24,25(OH)2D3], hatchability equivalent to that with hens given vitamin D3 is obtained. These results suggest a biological role for 24,25(OH)2D3 not previously recognized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henry, H L -- Norman, A W -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):835-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684411" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chickens/*physiology ; Dihydroxycholecalciferols/*pharmacology ; Female ; Growth/drug effects ; Hydroxycholecalciferols/*pharmacology ; Ovulation/*drug effects ; Reproduction/*drug effects ; Sexual Maturation/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 56 (1994), S. 236-244 
    ISSN: 0730-2312
    Keywords: diurnal cycles ; Zeitgeber ; vitamin D ; bone ; hydroxylase ; renal cells ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Computer simulation of calcium homeostasis in chicks predicted an oscillatory behavior of bone calcium flow and kidney 25-hydroxyvitamin D3-1 hydroxylase with a periodicity of 56 h and a 9 h phase difference between the two signals. In growing chickens subjected to a light: dark cycle of 22:2 h, and intravenously dosed with 45Ca, the temporal changes in plasma 45Ca could be described by an exponential decline with superimposed diurnal oscillations. The activity of the renal 25-hydpoxyvitamil D3-1-hydroxylase in chicks subjected to a 12:12 h light: dark cycle ALSO followed diupnal oscillations, with a ladir at the beginning of the light period and a peak 12 h later. The production of 1,25-dihydroxyvitamin D3 by primary cultures of chicken kidney cells mscillated with a periodicity of 5.6 h or shorter. It is suggested that despite the differences in phase and periodicity between the simulation predictions and actual results, the oscillations in both 1-hydroxylase and bone calcium flow could be coupled through the hormonal systems involved in regulation of plasma calcium.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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