Publication Date:
1978-01-06
Description:
Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mullin, B R -- Pacuszka, T -- Lee, G -- Kohn, L D -- Brady, R O -- Fishman, P H -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):77-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD 20014, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569488" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cattle
;
Cell Membrane/metabolism
;
Gangliosides/chemistry/*metabolism/pharmacology
;
Sialic Acids/analysis
;
Thyroid Gland/*metabolism
;
Thyrotropin/antagonists & inhibitors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
