Publication Date:
2008-12-17
Description:
Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faure-Andre, Gabrielle -- Vargas, Pablo -- Yuseff, Maria-Isabel -- Heuze, Melina -- Diaz, Jheimmy -- Lankar, Danielle -- Steri, Veronica -- Manry, Jeremy -- Hugues, Stephanie -- Vascotto, Fulvia -- Boulanger, Jerome -- Raposo, Graca -- Bono, Maria-Rosa -- Rosemblatt, Mario -- Piel, Matthieu -- Lennon-Dumenil, Ana-Maria -- New York, N.Y. -- Science. 2008 Dec 12;322(5908):1705-10. doi: 10.1126/science.1159894.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM U653, Institut Curie, 12 rue Lhomond, 75005, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19074353" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen Presentation
;
Antigens, Differentiation, B-Lymphocyte/genetics/*metabolism
;
Cathepsins/genetics/metabolism
;
*Cell Movement
;
Dendritic Cells/*immunology/physiology
;
Endocytosis
;
Histocompatibility Antigens Class II/genetics/*metabolism
;
Lipopolysaccharides/immunology
;
Lymph Nodes/cytology/immunology
;
Lysosomes/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Myosin Type II/*metabolism
;
Phosphorylation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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