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  • 1
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    Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-20
    Description: MAP kinase phosphatase-3 (MKP-3) dephosphorylates phosphotyrosine and phosphothreonine and inactivates selectively ERK family mitogen-activated protein (MAP) kinases. MKP-3 was activated by direct binding to purified ERK2. Activation was independent of protein kinase activity and required binding of ERK2 to the noncatalytic amino-terminus of MKP-3. Neither the gain-of-function Sevenmaker ERK2 mutant D319N nor c-Jun amino-terminal kinase-stress-activated protein kinase (JNK/SAPK) or p38 MAP kinases bound MKP-3 or caused its catalytic activation. These kinases were also resistant to enzymatic inactivation by MKP-3. Another homologous but nonselective phosphatase, MKP-4, bound and was activated by ERK2, JNK/SAPK, and p38 MAP kinases. Catalytic activation of MAP kinase phosphatases through substrate binding may regulate MAP kinase activation by a large number of receptor systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Camps, M -- Nichols, A -- Gillieron, C -- Antonsson, B -- Muda, M -- Chabert, C -- Boschert, U -- Arkinstall, S -- New York, N.Y. -- Science. 1998 May 22;280(5367):1262-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A., CH-1228 Plan-les-Ouates, Geneva, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9596579" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; COS Cells ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & ; inhibitors/genetics/*metabolism ; Catalysis ; Dual Specificity Phosphatase 6 ; Enzyme Activation ; Epidermal Growth Factor/pharmacology ; Mitogen-Activated Protein Kinase 1 ; Mitogen-Activated Protein Kinase 12 ; Mitogen-Activated Protein Kinase 9 ; *Mitogen-Activated Protein Kinases ; Molecular Sequence Data ; Mutation ; Phosphorylation ; Protein Kinases/metabolism ; Protein Tyrosine Phosphatases/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Transfection ; p38 Mitogen-Activated Protein Kinases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Marrying Social Media Approaches and Space Flight Control: Eight Years at SpaceOps (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Three previous SpaceOps papers [1-3] - published in 2010, 2012 (honored by the Conference as a "Best Paper"), and 2014 - have discussed paths to using social media concepts and techniques to enhance space flight controller effectiveness by a) reducing clutter of nonverbal communications (e.g., visual flow with minimal headers and shared content instead of multiple copies), b) moving some voice communication to non-verbal transmission (virtually eliminating "say again" requests because non-verbal comm can be re-read), thus making remaining voice comm easier to focus on, and c) reducing short-term and long-term flight stress on flight control personnel. This paper shows how Marshall Space Flight Center's (MSFC) ISS Payload Operations Integration Center (POIC) is realizing the above goals via the Communications Dashboard (CommDash) software suite deployed in 2017 (including enhancements to the Console Log Tool (CoLT) discussed in earlier papers). Two larger-scope benefits spawned by CommDash evolution are also chronicled: a) emergence of an Agile Software Development (ASD) process adapted to the not-always-nimble environment of government projects, and b) the sprouting of a Human Factors Engineering (HF or HFE) community of practice within MSFC's Payload and Mission Operations Division (PMOD).
    Keywords: Communications and Radar
    Type: M18-6674 , International Conference on Space Operations (SpaceOps 2018); May 28, 2018 - Jun 01, 2018; Merseille; France
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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