Publication Date:
1980-03-07
Description:
Nuclear receptors for both estradiol and progesterone were present in twofold higher concentrations in implantation sites than in nonimplantation regions of the endometrium of 6-day pregnant rats. Decidualization in the absence of an embryo was not accompanied by a similar increase in the concentration of nuclear receptors. Moreover, this difference in receptor distribution between the implantation and nonimplantation areas persisted when a major part of the maternal supply of sex steroids was suppressed by ovariectomy on day 5 of pregnancy. These results support the hypothesis that steroids originating from the embryo affect the endometrial implantation site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logeat, F -- Sartor, P -- Hai, M T -- Milgrom, E -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1083-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355273" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blastocyst/*metabolism
;
Castration
;
Cell Nucleus/metabolism
;
Decidua/metabolism
;
Endometrium/*metabolism/ultrastructure
;
Female
;
Gestational Age
;
Pregnancy
;
Pseudopregnancy
;
Rats
;
Receptors, Estrogen/*metabolism
;
Receptors, Progesterone/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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