Publication Date:
2009-04-04
Description:
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991140/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991140/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, Olaf -- Bhardwaj, Ratan D -- Bernard, Samuel -- Zdunek, Sofia -- Barnabe-Heider, Fanie -- Walsh, Stuart -- Zupicich, Joel -- Alkass, Kanar -- Buchholz, Bruce A -- Druid, Henrik -- Jovinge, Stefan -- Frisen, Jonas -- P41 GM103483/GM/NIGMS NIH HHS/ -- P41 RR013461/RR/NCRR NIH HHS/ -- P41 RR013461-11/RR/NCRR NIH HHS/ -- RR13461/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 3;324(5923):98-102. doi: 10.1126/science.1164680.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342590" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Aged
;
Aging
;
Carbon Radioisotopes/analysis
;
Cell Count
;
Cell Nucleus/chemistry
;
Cell Nucleus Division
;
Cell Proliferation
;
Cell Separation
;
DNA/*biosynthesis
;
Echocardiography, Doppler, Color
;
Humans
;
Middle Aged
;
Models, Cardiovascular
;
Myocytes, Cardiac/*cytology/metabolism
;
Nuclear Weapons
;
Polyploidy
;
Radiometric Dating
;
Stem Cells/cytology
;
Troponin I/analysis
;
Troponin T/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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