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  • 1
    Electronic Resource
    Electronic Resource
    Further study of the correlation between na-pump activity and membrane chemosensitivity (1985)
    Springer
    Cellular and molecular neurobiology 5 (1985), S. 231-243 
    Details
    ISSN: 1573-6830
    Keywords: acetylcholine ; γ-aminobutyric acid ; α-bungarotoxin ; membrane receptor ; phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Using internally dialyzed neurons ofHelix, we have examined the effects of sodium-pump activity and intracellular ATP concentration on transmembrane currents induced by acetylcholine (ACh) andγ-aminobutyric acid (GABA). We also report on the effects of pump activity and levels of intracellular ATP on binding byHelix ganglia of3H-α-bungarotoxin (3H-α-BT) and3H-GABA. 2. Both ouabain-containing and potassium-free solutions depressed the neurotransmitter-induced transmembrane current of one type of dialyzed neurons. 3. An increase in the intracellular ATP concentration led to a depression of ACh-induced currents and to the disappearance of the blocking effect of ouabain on these currents. Intracellular ADP had a similar but smaller effect on transmitter-induced currents, and intracellular AMP was ineffective. The depressing effect of internal ATP on ACh-induced currents was absent in the presence of an inhibitor of membrane phosphorylation (dinitrophenol). 4. The binding of tritium-labeledα-BT and GABA to the membranes was depressed by both ouabain-containing and K-free solutions and also by compounds (theophylline and NaF) which increase the levels of intracellular ATP. 5. The results suggest that the Na pump modulates the affinity of ACh and GABA membrane receptors by the regulation of the phosphorylated state of membrane receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711009
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of short-chain fatty acids on the neuronal membrane functions ofHelix pomatia. II. cholinoreceptive properties (1986)
    Springer
    Cellular and molecular neurobiology 6 (1986), S. 165-175 
    Details
    ISSN: 1573-6830
    Keywords: membrane receptor ; fluidity ; acetylcholine ; decenoic acid ; valeric acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. We have examined the effects of short-chain fatty acids on acetylcholine (ACh)-induced transmembrane currents using internally dialized neurons ofHelix. 2. Decenoic acid, which increased the fluidity of excitable membranes, caused dramatic changes in the voltage sensitivity of ACh currents consisting of an ACh-induced increase in membrane permeability for K+ and Na+ ions and a shift of theE rev of these ACh responses to more positive potentials. Valeric acid, which did not change the membrane fluidity, had no effect on this type of ACh response. 3. Changes of theE Na andE Cl had no effect on the size of the decenoic acid-induced shift of theE rev. But the influence of decenoic acid on the voltage sensitivity of ACh-induced currents almost disappeared after the change of theE K by the reduction of the internal K concentration. 4. Decenoic acid had no effect on ACh responses in which K+ ions were not involved in the generation of ACh-induced currents. 5. The results suggest that decenoic acid-induced changes in membrane fluidity modulate cholinoreceptive properties of the neuronal membrane by the inhibition of the K+ carrier involved in the generation of ACh responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711068
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetic fields alter electrical properties of solutions and their physiological effects (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 15 (1994), S. 133-142 
    Details
    ISSN: 0197-8462
    Keywords: magnetic field ; neuron ; conductance ; cell volume ; Ca ; water of hydration ; cyclic nucleotide ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Calcium chloride and snail physiological salt solutions were exposed to static magnetic fields (2.3-350 mT), and the physical properties of the solutions as well as their biologic effects were studied. Our preliminary observations show that these fields alter physicochemical properties of CaCl2 solutions and the functional effects of physiological solutions. Experiments on CaCl2 solutions demonstrated field-dependent changes of electrical conductivity, with the magnitude and the direction of conductivity change being a function of both concentration and field intensity. The changes in conductivity were maintained for periods in excess of 1 h after exposure. Conductivity changes were not found after exposure of physiological solutions to static magnetic fields, but changes of biological consequence did occur. Other experiments showed that there were several changes in cellular function observed in ganglia and isolated neurons of Helix pomatia when the perfusing medium was changed from the normal physiologic solution to the same solution after exposure to magnetic fields. These changes include membrane depolarization and increased action potential discharge, reduced uptake of Ca into cells, altered content of cyclic nucleotides in ganglia, and increased volume of isolated cell bodies. A change in hydration of calcium ions may be one of the consequences of magnetic-field exposure, and in physiological solutions this change may have functional consequences. © 1994 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250150205
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