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  • 1
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    Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR (2013)
    Oxford University Press
    Details
    Publication Date: 2013-09-06
    Description: Cancers are heterogeneous and genetically unstable. New methods are needed that provide the sensitivity and specificity to query single cells at the genetic loci that drive cancer progression, thereby enabling researchers to study the progression of individual tumors. Here, we report the development and application of a bead-based hemi-nested microfluidic droplet digital PCR (dPCR) technology to achieve ‘quantitative’ measurement and single-molecule sequencing of somatically acquired carcinogenic translocations at extremely low levels (〈10 –6 ) in healthy subjects. We use this technique in our healthy study population to determine the overall concentration of the t(14;18) translocation, which is strongly associated with follicular lymphoma. The nested dPCR approach improves the detection limit to 1 x 10 –7 or lower while maintaining the analysis efficiency and specificity. Further, the bead-based dPCR enabled us to isolate and quantify the relative amounts of the various clonal forms of t(14;18) translocation in these subjects, and the single-molecule sensitivity and resolution of dPCR led to the discovery of new clonal forms of t(14;18) that were otherwise masked by the conventional quantitative PCR measurements. In this manner, we created a quantitative map for this carcinogenic mutation in this healthy population and identified the positions on chromosomes 14 and 18 where the vast majority of these t(14;18) events occur.
    Keywords: Polymorphism/mutation detection
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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    PAPER CURRENT
  • 2
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    Design, Fabrication and Test of Multi-Fiber Laminates (1975)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Unidirectional and angleply multifiber laminates were tested for improved impact strength and other mechanical properties. The effects of several variables on the mechanical properties of epoxy matrix materials were described. These include fiber type (HMS and AS graphites, glass, and Kevlar 49), ratio of primary to hybridizing fiber and hybrid configuration. It is demonstrated that AS graphite/S glass in an intraply configuration results in the best combination of static and Charpy impact properties as well as superior ballistic impact resistance. Pendulum impact tests which were conducted on thin specimens are shown to produce different ranking of materials than tests conducted on standard thickness Charpy specimens. It is shown that the thin specimen results are in better agreement with the ballistic impact data. Additional static test data are reported as a function of temperature for the seven best hybrid configurations having epoxy, polyimide (PMR-15) and polyphenylquinoxaline resins as the matrix.
    Keywords: COMPOSITE MATERIALS
    Type: NASA-CR-134763 , R75-911730-15
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Multi-Fiber Composites (1976)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Resin matrix composites having improved resistance to foreign object damage in gas turbine engine fan blade applications were developed. Materials evaluated include epoxy matrix graphite/glass and boron/glass hybrids, thermoplastic matrix boron/glass hybrids, and superhybrids consisting of graphite/epoxy, boron/aluminum, and titanium alloy sheets. Static, pendulum impact, and ballistic impact test results are reported for all materials. Superhybrid blade like specimens are shown to be capable of withstanding relatively severe ballistic impacts from gelatin spheres without fracture. The effects of ply configuration and projectile angle of incidence on impact behavior are described. Predictions of surface strains during ballistic impact are presented and shown to be in reasonable agreement with experimental measurements.
    Keywords: COMPOSITE MATERIALS
    Type: NASA-CR-135062 , R76-912098-11
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Increasing the FOD tolerance of composites (1978)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: An experimental program was conducted for the purpose of increasing the foreign object damage tolerance of resin matrix composites in gas turbine engine fan blade applications. The superhybrid concept consisting of a resin matrix composite core surrounded by a sheath of boron/aluminum and titanium was found to be the most promising approach.
    Keywords: COMPOSITE MATERIALS
    Type: Selective application of materials for products and energy; Twenty-third National Symposium and Exhibition; May 02, 1978 - May 04, 1978; Anaheim, CA
    Format: text
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    NASA TECHNICAL REPORTS
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