ISSN:
1432-1041
Keywords:
hyperlipoproteinaemia (Type II/Type IV)
;
gemfibrozil
;
CI-924
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary CI-924 (CI), 5,5′-[[1,1′-biphenyl]-2,5-diylbis(oxy)]bis[2,2-dimethylpentanoic acid] is chemically similar to gemfibrozil. Patients with Type II (n=13) and Type IV (n=22) hyperlipoproteinaemia (HLP) were maintained 12 weeks on a baseline diet containing 55% sugar, 15% protein 30% fat and 〈300 mg cholesterol daily to stabilize weight and lipids. They were then entered in a parallel group double-blinded protocol and received 0, 300, 600, or 1200 mg CI p.o. daily for 12 weeks. CI consistently elevated anti-atherogenic HDL and lowered VLDL at 600 mg/day in both Type II and Type IV HPL at 8 weeks. In Type II patients, CI lowered cholesterol, decreased LDL/HDL and increased ApoA-I. In Type IV patients, CI also lowered TC while elevating LDL and ApoA-II. CI had no effect on Apo-B, LDL-ApoB, or Apo-E.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558127
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