ISSN:
0021-9304
Keywords:
microencapsulation
;
diabetes
;
atomic force microscopy
;
surface characterization
;
immunoisolation device
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
The surface morphology of the microcapsule used as a bioartificial pancreas was examined by atomic force microscopy (AFM) under ambient conditions in a liquid environment. The standard contact mode was used for imaging. The capsules exhibited different morphologies and surface roughness depending on the composition of the cation solution: namely, the mole ratio of antigelling and gelling cations [Na+]/[Ca2+]. Surface roughness parameters obtained by AFM measurements provide quantitative information on the surface properties of the capsular membrane. In this respect, AFM can be considered a valuable technique complementary to optical microscopy in providing feedback for capsule optimization. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 461-467, 1998.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
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