Publication Date:
1998-05-09
Description:
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veazey, R S -- DeMaria, M -- Chalifoux, L V -- Shvetz, D E -- Pauley, D R -- Knight, H L -- Rosenzweig, M -- Johnson, R P -- Desrosiers, R C -- Lackner, A A -- AI25328/AI/NIAID NIH HHS/ -- AI38559/AI/NIAID NIH HHS/ -- DK50550/DK/NIDDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Apr 17;280(5362):427-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Post Office Box 9102, Southborough, MA 01772, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9545219" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CD4 Lymphocyte Count
;
CD4-Positive T-Lymphocytes/*immunology/virology
;
Colon/*immunology/virology
;
Immunity, Mucosal
;
Immunologic Memory
;
Intestinal Mucosa/immunology/virology
;
Intestine, Small/*immunology/virology
;
Lymphocyte Activation
;
Lymphocytes/immunology/virology
;
Lymphoid Tissue/immunology/virology
;
Macaca mulatta
;
Macrophages/virology
;
Male
;
Receptors, Interleukin-2/analysis
;
Simian Acquired Immunodeficiency Syndrome/*immunology/*virology
;
Simian Immunodeficiency Virus/immunology/pathogenicity/*physiology
;
Viral Load
;
Virulence
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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