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  • 1
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    Widespread occurrence in frogs and toads of skin compounds interacting with the ouabain site of Na+, K+-ATPase (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: Amphibians of the family Bufonidae contain high levels of skin compounds that both inhibit Na+- and K+-dependent adenosinetriphosphatase and antagonize the binding of ouabain to the enzyme. In species of Bufo and Atelopus, these compounds are relatively nonpolar bufodienolides, whereas Dendrophryniscus and Melanophryniscus contain more polar compounds of unknown structure. Skin extracts from 30 of 48 species of frogs representing an additional eight families contained relatively low levels of compounds that inhibit binding of ouabain to Na+,K+-adenosinetriphosphatase. The widespread occurrence of low levels of inhibitory compounds is consonant with the role for these compounds as physiological regulators of Na+,K+-adenosinetriphosphatase in amphibian skin; high levels in the Bufonidae probably also serve as a defense against some predators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flier, J -- Edwards, M W -- Daly, J W -- Myers, C W -- New York, N.Y. -- Science. 1980 May 2;208(4443):503-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245447" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura/*metabolism ; Binding Sites ; Bufanolides/pharmacology ; Ouabain/antagonists & inhibitors/*metabolism ; Skin/analysis/enzymology/*metabolism ; Sodium-Potassium-Exchanging ATPase/*metabolism ; Species Specificity ; Tissue Extracts/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Oculoparalytic illusion: visual-field dependent spatial mislocalizations by humans partially paralyzed with curare (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-09
    Description: In darkness, observers partially paralyzed with curare make large (greater thn 20 degrees) gaze- and dosage-dependent errors in visually localizing eye-level-horizontal and median planes, in matching the location of a sound to a light, and in pointing at a light. In illuminated, structured visual localization and pointing are accurate but errors in auditory-to-visual matches remain. Defects in extraretinal eye position information are responsible for all errors. The influence of extraretinal eye position information on visual localization is suppressed by a structured visual field but is crucial both in darkness and for intersensory localization if visual capture is prevented.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matin, L -- Picoult, E -- Stevens, J K -- Edwards, M W Jr -- Young, D -- MacArthur, R -- EY 03198/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):198-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063881" target="_blank"〉PubMed〈/a〉
    Keywords: Auditory Perception/physiology ; *Eye Movements/drug effects ; Humans ; Proprioception ; Tubocurarine/pharmacology ; Visual Fields ; Visual Perception/drug effects/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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