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  • 1
    ISSN: 1432-1041
    Keywords: Budesonide ; liver ; man ; sulphotransferase ; testosterone ; drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Budesonide, a corticosteroid used in the treatment of asthma and allergic reactions, is almost entirely cleared by metabolism in man. We describe the sulphation of budesonide in human liver and lung and provide evidences that the sulphation of budesonide is catalysed by testosterone sulphotransferase. A rapid and reproducible radiometric assay for budesonide sulphotransferase is described. Liver specimens were obtained from 35 men and 65 women and lung specimens from 2 women and 17 men. The average hepatic budesonide sulphation rate was significantly higher in men (41.1 pmol·min−1·ml−1) than women (28.2 pmol·min−1·mg−1). In the lung, the mean budesonide sulphation rate was 5.0 pmol·min−1·mg−1. Testosterone strongly inhibited the hepatic sulphation of budesonide, whereas p-nitrophenol and dopamine were poor inhibitors; the IC50 was 7.0 uM (testosterone), 320 uM (p-nitrophenol) and 510 uM (dopamine). The hepatic rates of testosterone, p-nitrophenol and dopamine sulphation were measured in the same samples assayed for budesonide sulphotransferase. There was a correlation between the hepatic rates of budesonide and testosterone sulphation (P〈0.001; r=0.810). The activity of testosterone sulphotransferase was significantly greater in men than women (22.0 vs. 17.2 pmol·min−1·mg−1), wheres those of dopamine and p-nitrophenol sulphotransferase were not sex dependent. The hepatic activity of budesonide sulphotransferase parallels that of testosterone suggesting that sulphation is an important reaction in the metabolism of budesonide.
    Type of Medium: Electronic Resource
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  • 2
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    In:  Nature, Edmonton, Conseil de l'Europe, vol. 325, no. 44, pp. 678-683, pp. B10410, (ISSN: 1340-4202)
    Publication Date: 1987
    Keywords: Seismology ; earth Core ; earth mantle ; Inhomogeneity ; Tomography ; Dziewonski
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  • 3
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    In:  Geophys. J. Int., Edmonton, Conseil de l'Europe, vol. 325, no. 44, pp. 678-683, pp. B10410, (ISSN: 1340-4202)
    Publication Date: 1991
    Keywords: P-waves ; Shear waves ; Seismology ; Velocity analysis ; Travel time ; GJI ; Dziewonski
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  • 4
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    In:  Computers & Geosciences, Oslo, Wiley, vol. 21, no. 2, pp. 279-288, pp. 1604, (ISSN: 1340-4202)
    Publication Date: 1995
    Keywords: Data analysis / ~ processing ; Discrimination ; Detectors ; Seismology
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  • 5
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    Kluwer Acad. Publ.
    In:  Professional Paper, Recent Evolution and Seismicity of the Mediterranean Region, Dordrecht, Kluwer Acad. Publ., vol. 23, no. Subvol. b, pp. 213-238, (ISBN: 3-540-23712-7)
    Publication Date: 1993
    Keywords: Seismology ; Source parameters
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  • 6
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    In:  Pageoph, Darmstadt, Wissenschaftliche Buchgesellschaft, vol. 158, no. 1-2, pp. 319-347, pp. L11308, (ISSN: 1340-4202)
    Publication Date: 2001
    Keywords: Seismology ; Location ; Modelling ; Three dimensional ; Nuclear explosion ; PAG
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  • 7
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    In:  Geophys. J. Int., Darmstadt, Wissenschaftliche Buchgesellschaft, vol. 135, no. 3-4, pp. 232-254, pp. L11308, (ISSN: 1340-4202)
    Publication Date: 1998
    Keywords: Location ; Seismology ; P-waves ; Travel time ; earth mantle ; Inhomogeneity ; GJI
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  • 8
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    Reidel Publ. Company
    In:  Bull., Polar Proj. OP-O3A4, Seismic Tomography, Dordrecht, 10+386 pp., Reidel Publ. Company, vol. 3, no. Subvol. b, pp. 251-274, (ISBN 0080419208)
    Publication Date: 1987
    Keywords: Tomography ; earth Core ; Seismology ; earth mantle ; Textbook of geophysics ; Inversion ; Dziewonski
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  • 9
    Publication Date: 2016-05-22
    Description: We measure ellipticity of teleseismic Rayleigh waves at 95 seismic stations in Northern Italy, for wave period between 10 and 110 s, using an automatic technique and a large volume of high-quality seismic recordings from over 500 global earthquakes that occurred in 2008–2014. Northern Italy includes a wide range of crustal structures, from the wide and deep Po Plain sedimentary basin to outcropping sedimentary and crystalline rocks in the Northern Apennines and Alps. It thus provides an excellent case for studying the influence of shallow earth structure on polarization of surface waves. The ellipticity measurements show excellent spatial correlation with geological features in the region, such as high ellipticity associated with regions of low seismic velocity in the Po Plain and low ellipticity values in faster, hard rock regions in the Alps and Apennine mountains. Moreover, the observed ellipticity values also relate to the thickness of the basement, as highlighted by observed differences beneath the Alps and the Apennines. Comparison between observations and predicted ellipticity from a reference crustal model of the region show substantial fit, particularly for T ~ 38 s data. Discrepancy for shorter wave period suggests that slight modifications of the model are needed, and that the ellipticity measurements could help to better constrain the shallow crustal structure of the region. Predictions for the Po Plain are larger than the observations by a factor of four or more and transition from retrograde to prograde Rayleigh wave motion at the surface for periods of T ~ 10–13 s is predicted for seismic stations in the plain. Analysis of corresponding real data indicates a possible detection of teleseismic prograde particle motion, but the weak teleseismic earthquake signals are mixed with ambient noise signals at the predicted, short, transition periods. Detection of the period of polarity inversion from the joint analysis of earthquake and ambient noise ellipticity measurements may provide further, stringent, constraints on the structure of sedimentary basins.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 10
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    Springer
    Publication Date: 2017-04-04
    Description: n/a
    Description: Published
    Description: 125-127
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: restricted
    Keywords: Core-mantle boundary topography ; Seismology ; 04. Solid Earth::04.01. Earth Interior::04.01.03. Mantle and Core dynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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