Publication Date:
2008-07-19
Description:
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamberlain, Samuel R -- Menzies, Lara -- Hampshire, Adam -- Suckling, John -- Fineberg, Naomi A -- del Campo, Natalia -- Aitken, Mike -- Craig, Kevin -- Owen, Adrian M -- Bullmore, Edward T -- Robbins, Trevor W -- Sahakian, Barbara J -- G0001354/Medical Research Council/United Kingdom -- G001354/Wellcome Trust/United Kingdom -- MC_U105559847/Medical Research Council/United Kingdom -- U1055.01.002.00001.01/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):421-2. doi: 10.1126/science.1154433.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Box 189, Cambridge CB2 0QQ, UK. srchamb@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635808" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Brain Mapping
;
Family
;
Female
;
Frontal Lobe/*physiopathology
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Obsessive-Compulsive Disorder/*physiopathology
;
Prefrontal Cortex/physiopathology
;
*Reversal Learning
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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