Publication Date:
1988-02-05
Description:
Gold-filled Sendai virus envelopes were fused with cell suspensions from the basal forebrain of fetal rat donors, and the resulting gold-labeled cells were transplanted into the neocortex of adult rat recipients. Not only did large numbers of labeled cells remain intact through 3 months in the neocortex, but sizable numbers migrated subcortically to the recipient's lesioned nucleus basalis region (a distance of 4 to 5 millimeters). Since this technique is capable of labeling most transplanted cells for long periods of time, it may be useful in determining the survival, migration, and connectivity of intracerebrally transplanted tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ardizzoni, S C -- Michaels, A -- Arendash, G W -- HD 17933/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1988 Feb 5;239(4840):635-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of South Florida, Tampa 33620.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2829355" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/cytology/embryology
;
Fetus
;
Gold
;
Nerve Tissue/*transplantation
;
Neurons/cytology/*transplantation
;
Parainfluenza Virus 1, Human
;
Rats
;
*Viral Envelope Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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