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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1992-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- DA-271-90-7408/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Jul 24;257(5069):494-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1353273" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Models, Neurological ; Muscle, Smooth, Vascular/physiology ; Neurons/*physiology ; Neurotransmitter Agents/*metabolism ; Nitric Oxide/*metabolism ; Second Messenger Systems ; Vasodilation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-03-26
    Description: Adenosine receptors associated with a reduction of adenylate cyclase and labeled by tritium-labeled cyclohexyladenosine can be solubilized from brain membranes with sodium cholate. Regulation of receptor binding by guanine nucleotides is retained in the soluble state. Influences of cations observed in membrane preparations of adenosine receptors are no longer detected with the solubilized receptors. The apparent retention of a complex of receptors and guanosine triphosphate binding but not cation binding protein in the soluble state may permit a molecular analysis of receptor regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gavish, M -- Goodman, R R -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1633-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280275" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Brain/*physiology ; Cations, Divalent/pharmacology ; Cattle ; Cell Membrane/metabolism ; Guanine Nucleotides/*pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Purinergic ; Solubility
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1981-05-15
    Description: Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peroutka, S J -- Lebovitz, R M -- Snyder, S H -- DA-00074/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 May 15;212(4496):827-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221567" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Behavior, Animal/*physiology ; Brain/*physiology ; Guanine Nucleotides/physiology ; Kinetics ; Male ; Rats ; Receptors, Serotonin/*physiology ; Serotonin/metabolism ; Spiperone/metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-08-29
    Description: Numerous peptides appear to be neurotransmitter candidates in the brain. Some, such as the opioid peptide enkephalins, neurotensin, and substance P, were first isolaterd from the brain. Peptides, such as cholecystokinin and vasoactive intestinal polypeptide, were known as intestinal hormones and later recognized as brain constituents. Certain hypothalamic-releasing hormones, pituitary peptides, and blood-derived peptides like angiotensin II and bradykinin, may also be central neurotransmitters. The diversity of localization of these peptides throughout the brain implies a multiplicity of potential roles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, S H -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):976-83.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157191" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensins/physiology ; Animals ; Bradykinin/physiology ; Brain/*physiology ; Carnosine/physiology ; Cholecystokinin/physiology ; Endorphins/physiology ; Gastrins/physiology ; Glucagon/physiology ; Humans ; Insulin/physiology ; Nerve Tissue Proteins/physiology ; Neurotensin/physiology ; Peptides/*physiology ; Pituitary Hormone-Releasing Hormones/physiology ; Receptors, Opioid/physiology ; Substance P/physiology ; Vasoactive Intestinal Peptide/physiology ; Vasopressins/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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