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  • Bone mineral density  (1)
  • Dual energy X-ray absorptiometry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Precision of dual x-ray absorptiometry and peripheral computed tomography using mobile densitometry units (1994)
    Springer
    Calcified tissue international 54 (1994), S. 219-223 
    Details
    ISSN: 1432-0827
    Keywords: Mobile bone densitometry ; Dual energy X-ray absorptiometry ; Peripheral QCT ; Long-term precision
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Irrespective of the method used for noninvasive bone mass determination, data comparison between different centers is a major problem as significant interunit variation may occur. We, therefore, have employed mobile densitometry units to reduce interunit variability in two large epidemiologic studies in Germany. Two cars were equipped with either two dual X-ray absorptiometry (DXA) instruments (QDR 1000 Hologic, USA) (car I) or a special purposed scanner for peripheral quantitative computed tomography (pQCT) (XCT 900, Stratec, FRG) (car II). The cars were moved across Germany 11,090 km and 1651 km during the studies over a period of 30 and 7 months, respectively. Precision in vitro was determined using hydroxyapatite phantoms. Forty-eight patients underwent duplicate measurements at the lumbar spine (n=22) and hip (n=26) for assessing reproducibility in vivo. Between the two series of scans, the car was moved 63 km. Long-term precision in vitro of the QDR 1000 instruments were 0.41% and 0.59% for BMD with no evidence of machine drift (rate of change per year 0.04% and 0.05%, respectively). Short-term reproductibility in vivo showed a coefficient of variation (cv) of 1.02% for spinal BMD (L2–L4) and 1.72% for femoral neck. Long-term precision in vitro of the pQCT scanner was 0.9%. Our study shows precision in vivo and in vitro and stability of the mobile densitometers similar to that achieved with stationary equipment. In conclusion, mobile densitometry may become a useful tool not only for epidemiologic surveys and clinical trials but also for routine evaluation in less densely populated areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301682
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dual-energy X-ray absorptiometry at the lumbar spine in German men and women: A cross-sectional study (1995)
    Springer
    Calcified tissue international 56 (1995), S. 350-354 
    Details
    ISSN: 1432-0827
    Keywords: Bone mineral density ; Dual-energy X-ray absorptiometry ; Reference range ; Exclusion criteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract A cross-sectional, population-based study of 238 randomly selected females and 224 males with German ethnic background (aged 20–80 years) was carried out to establish lumbar spine bone mineral density (BMD) values, using dual X-ray absorptiometry (DXA), for a German population. Comparison was made to the reference range provided by the manufacturer of the DXA equipment. No sex difference in peak spine BMD was found in our study (1.091±0.114 g/cm2 for males versus 1.070±0.113 g/cm2 for females, n.s.). Different patterns of bone loss could be detected in both sexes. In premenopausal women there was no significant correlation between age and BMD (y = 1.044 + 0.00047x, r=0.03, P=0.73) whereas reduction of female BMD at the spine was demonstrated in postmenopausal women (y = 1.189−0.0041x, r=-0.28, P=0.01), underscoring the important role of the menopause for later manifestation of spinal osteoporosis in women. In contrast, in males we found no significant change of BMD with aging (y = 1.071−0.0007x, r=-0.08, P=0.25). Employing commonly used exclusion criteria, BMD values of the study subjects were found mostly within the normal range of BMD. The major finding of our study was good concordance between female data of our study population and the reference data provided by the manufacturer. Clinically significant discrepancies between our data and the Hologic reference range for males could be detected. Our data on males (30–39 years of age) were up to 7% lower than those provided by the manufacturer, probably due to differences in sampling procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301600
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    Paper (German National Licenses)
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