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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 152 (1988), S. 231-236 
    ISSN: 0006-291X
    Keywords: [abr] NT; neurotensin ; [abr] PG; pentagastrin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 152 (1988), S. 231-236 
    ISSN: 0006-291X
    Keywords: [abr] NT; neurotensin ; [abr] PG; pentagastrin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 49 (1996), S. 273-278 
    ISSN: 1432-1041
    Keywords: Key words Moclobemide ; Selegiline; interaction ; pharmacodyamics ; tyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract. Objective: The objectives of this double-blind study were to assess the tolerability and i.v. tyramine pressor response during combined treatment with moclobemide and selegiline. Subjects: Two parallel groups of 12 healthy male and female subjects were treated with 200 mg moclobemide or 5 mg selegiline b.d. for 14 days. On Day 7, selegiline or moclobemide was added to the other treatment. IV tyramine pressor tests were conducted at baseline and at steady state during mono- and combined treatment. Results: Treatment with moclobemide and selegiline alone was well tolerated, whereas combined treatment led to a slight increase in adverse events. Tyramine pressor sensitivity during moclobemide, selegiline and moclobemide + selegiline treatment was enhanced, on average, by 2.4-, 1.3- and 8.4-times, respectively. Conclusion: Although combined treatment with moclobemide and selegiline was well tolerated, the supra-additive potentiation of the tyramine pressor effects means that dietary restriction of tyramine intake will be necessary during such combination therapy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 49 (1996), S. 273-278 
    ISSN: 1432-1041
    Keywords: Moclobemide ; Selegiline ; interaction ; pharmacodyamics ; tyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The objectives of this double-blind study were to assess the tolerability and i.v. tyramine pressor response during combined treatment with moclobemide and selegiline. Subjects: Two parallel groups of 12 healthy male and female subjects were treated with 200 mg moclobemide or 5 mg selegiline b.d. for 14 days. On Day 7, selegiline or moclobemide was added to the other treatment. IV tyramine pressor tests were conducted at baseline and at steady state during mono- and combined treatment. Results: Treatment with moclobemide and selegiline alone was well tolerated, whereas combined treatment led to a slight increase in adverse events. Tyramine pressor sensitivity during moclobemide, selegiline and moclobemide + selegiline treatment was enhanced, on average, by 2.4-, 1.3- and 8.4-times, respectively. Conclusion: Although combined treatment with moclobemide and selegiline was well tolerated, the supra-additive potentiation of the tyramine pressor effects means that dietary restriction of tyramine intake will be necessary during such combination therapy.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical chemistry accounts 93 (1996), S. 333-342 
    ISSN: 1432-2234
    Keywords: van der Waals complex ; Transition states ; Extended basis sets ; Bond functions ; Electronic correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The stationary points on the intermolecular potential energy surface (PES) for the HF ... ClF complex have been investigated at the second-order Møller-Plesset perturbation theory (MP2) level using various extended bais sets, including diffuse functions, and also bond functions. The last ones were placed at different intermolecular positions, for distinct stationary points. The basis set superposition errors (BSSE) were accounted for using the counterpoise method. Besides the anti-H-bonded and H-bonded minimum energy structures, four transition state structures were also located on the PES. It was shown that higher polarization functions are required for the description of the anti H-bonded isomer and diffuse functions had to be included for the H-bonded isomer. The bond functions are able to replace thef (Cl, F) andd(H) polarization functions at a lower computational cost. However, for the H-bonded isomer intramolecular electron correlation also plays an important role. So we have to use diffuse nucleus centered polarization functions for an adequate description of intermolecular and intramolecular correlation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0040-5744
    Keywords: Key words: van der Waals complex ; Transition states ; Extended basis sets ; Bond functions ; Electronic correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary.  The stationary points on the intermolecular potential energy surface (PES) for the HF…ClF complex have been investigated at the second-order Møller–Plesset perturbation theory (MP2) level using various extended bais sets, including diffuse functions, and also bond functions. The last ones were placed at different intermolecular positions, for distinct stationary points. The basis set superposition errors (BSSE) were accounted for using the counterpoise method. Besides the anti-H-bonded and H-bonded minimum energy structures, four transition state structures were also located on the PES. It was shown that higher polarization functions are required for the description of the anti H-bonded isomer and diffuse functions had to be included for the H-bonded isomer. The bond functions are able to replace the f (Cl, F) and d(H) polarization functions at a lower computational cost. However, for the H-bonded isomer intramolecular electron correlation also plays an important role. So we have to use diffuse nucleus centered polarization functions for an adequate description of intermolecular and intramolecular correlation.
    Type of Medium: Electronic Resource
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