Publication Date:
2013-12-18
Description:
An amputated salamander limb regenerates the correct number of segments. Models explaining limb regeneration were largely distinct from those for limb development, despite the presence of common patterning molecules. Intercalation has been an important concept to explain salamander limb regeneration, but clear evidence supporting or refuting this model was lacking. In the intercalation model, the first blastema cells acquire fingertip identity, creating a gap in positional identity that triggers regeneration of the intervening region from the stump. We used HOXA protein analysis and transplantation assays to show that axolotl limb blastema cells acquire positional identity in a proximal-to-distal sequence. Therefore, intercalation is not the primary mechanism for segment formation during limb regeneration in this animal. Patterning in development and regeneration uses similar mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roensch, Kathleen -- Tazaki, Akira -- Chara, Osvaldo -- Tanaka, Elly M -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1375-9. doi: 10.1126/science.1241796.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Deutsche Forschungsgemeinschaft (DFG)-Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24337297" target="_blank"〉PubMed〈/a〉
Keywords:
Ambystoma mexicanum
;
Animals
;
Body Patterning
;
Extremities/anatomy & histology/*physiology
;
Homeodomain Proteins/*metabolism
;
Molecular Sequence Data
;
*Regeneration
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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