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  • 1
    Electronic Resource
    Electronic Resource
    The complete cDNA derived sequence of the rat prolyl 4-hydroxylase α subunit
    Amsterdam : Elsevier
    Gene 149 (1994), S. 391-392 
    Details
    ISSN: 0378-1119
    Keywords: Collagen biosynthesis ; fibrosis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(94)90188-0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The histamine H1-receptor antagonist binding site. Part I: Active conformation of cyproheptadine (1991)
    Springer
    Journal of computer aided molecular design 5 (1991), S. 357-370 
    Details
    ISSN: 1573-4951
    Keywords: MNDO ; Molecular modeling ; Superimposition ; Boat conformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The active conformation of several histamine H1-antagonists is investigated. As a template molecule we used the antagonist cyproheptadine, which consists of a piperidylene ring connected to a tricyclic system. The piperidylene moiety is shown to be flexible. The global minimum is a chair conformation but, additionally, a second chair and various boat conformations have to be considered, as their energies are less than 5 kcal/mol above the energy of the global minimum. Two semi-rigid histamine H1-antagonists, phenindamine and triprolidine, were fitted onto the various conformations of cyproheptadine in order to derive the pharmacologically active conformation of cyproheptadine. At the same time, the active conformation of both phenindamine and triprolidine was derived. It is demonstrated that, within the receptor-bound conformation of cyproheptadine, the piperidylene ring most probably exists in a boat form.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00126668
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    Paper (German National Licenses)
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  • 3
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    Geophysical precursors of the July-August 2019 paroxysmal eruptive phase and their implications for Stromboli volcano (Italy) monitoring (2020)
    Nature P. G.
    Details
    Publication Date: 2020-06-25
    Description: Two paroxysmal explosions occurred at Stromboli volcano in the Summer 2019, the first of which, on July 3, caused one fatality and some injuries. Within the 56 days between the two paroxysmal explosions, effusive activity from vents located in the summit area of the volcano occurred. No significant changes in routinely monitored parameters were detected before the paroxysmal explosions. However, we have calculated the polarization and the fractal dimension time series of the seismic signals from November 15, 2018 to September 15, 2019 and we have recognized variations that preceded the paroxysmal activity. In addition, we have defined a new parameter, based on RSAM estimation, related to the Very Long Period events, called VLP size, by means of which we have noticed significant variations through the whole month preceding the paroxysm of July 3. In the short term, we have analyzed the signals of a borehole strainmeter installed on the island, obtaining automatic triggers 10 minutes and 7.5 minutes before the July 3 and the August 28 paroxysms, respectively. The results of this study highlight mid-term seismic precursors of paroxysmal activity and provide valuable evidence for the development of an early warning system for paroxysmal explosions based on strainmeter measurements
    Description: This work benefited from funds of the EU (DG ECHO) Project EVE n. 826292 and was partially supported by the project INGV-FISR-2017 “Sale Operative Integrate e Reti di Monitoraggio del Futuro: l’INGV 2.0”. The data used in this study were provided by the Istituto Nazionale di Geofisica e Vulcanologia (Osservatorio Vesuviano, Osservatorio Etneo). The authors are also grateful to the Italian Presidenza del Consiglio dei Ministri- Dipartimento della Protezione Civile (DPC) for supporting the monitoring activities at Stromboli.
    Description: Published
    Description: 10296
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Keywords: Stromboli ; volcano ; precursors ; early warning ; seismic precursor
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    Challenges in UV camera-based real-time SO2 flux monitoring: insights from 5 years of continuous observations at Etna ad Stromboli (2019)
    Miscellanea INGV
    Details
    Publication Date: 2019-01-24
    Description: The advent of UV cameras has recently paved the way to volcanic SO2 flux observations of much improved temporal and spatial resolution, and has thus contributed to expanding use and utility of SO2 fluxes in volcano monitoring. Recently, the first examples of permanent UV camera systems have appeared that are now opening the way to routine fully automated monitoring of the volcanic SO2 flux at high-rate, and continuously (daily hours only). In 2014, using funding from the FP7-ERC project “Bridge” (http://www.bridge.unipa.it/), we deployed a network of 4 permanent UV cameras at Etna and Stromboli volcanoes (Sicily) that has been operating regularly since then. Using a suite of custom-built codes, data streamed by the UV camera are automatically processed and telemetered, allowing nearly real-time visualization and analysis of SO2 fluxes. Here, we summarise the key results obtained during the last 5 years of continuous observations (2014-2018) to demonstrate potentials and challenges in real-time continuous SO2 flux monitoring with UV cameras. We show that the spatially resolved SO2 flux time-series delivered by the UV camera allow effectively tracking migration in volcanic activity from the Central to New South-East Crater (Etna), and shifts in degassing activity along the crater terrace (Stromboli). At both volcanoes, the high temporal of UV cameras allows capturing the escalation in active (strombolian) SO2 degassing that typically precedes onset of paroxysmal (Etna in 2014-2016) or effusive (Stromboli in 2014) activity, and to quantify for the first time the syn- explosive SO2 budget for larger-scale explosions, including 2 paroxysmal lava fountains (Etna) and 1 major explosion (Stromboli). We finally demonstrate the ability of our automatic camera systems to capture temporal changes in SO2 flux regime, and thus to “live” monitoring degassing and eruptive behaviors at active volcanoes.
    Description: Published
    Description: Napoli
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Keywords: UV Camera ; SO2 Flux Monitoring ; Etna ; Stromboli
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
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