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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of computer aided molecular design 5 (1991), S. 357-370 
    ISSN: 1573-4951
    Keywords: MNDO ; Molecular modeling ; Superimposition ; Boat conformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The active conformation of several histamine H1-antagonists is investigated. As a template molecule we used the antagonist cyproheptadine, which consists of a piperidylene ring connected to a tricyclic system. The piperidylene moiety is shown to be flexible. The global minimum is a chair conformation but, additionally, a second chair and various boat conformations have to be considered, as their energies are less than 5 kcal/mol above the energy of the global minimum. Two semi-rigid histamine H1-antagonists, phenindamine and triprolidine, were fitted onto the various conformations of cyproheptadine in order to derive the pharmacologically active conformation of cyproheptadine. At the same time, the active conformation of both phenindamine and triprolidine was derived. It is demonstrated that, within the receptor-bound conformation of cyproheptadine, the piperidylene ring most probably exists in a boat form.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 29 (1998), S. 609-617 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Microstructural, mechanical and corrosive properties of friction stir welded aluminium jointsFriction stir welding (FSW) is a novel solid state welding process. It allows joining of high strength aluminum alloys, generally considered as difficult-to-weld with conventional technologies, without loss in joint strength. Results of investigations on selfmade FSW butt joints of the aluminum alloys 2024-T3 and 6013-T4 are presented. First, the microstructure of the weld seam and heat affected zone is characterised metallographically and by hardness measurements. By tensile, fatigue endurance (SN) and fatigue crack propagation tests it is demonstrated, that especially the FSW-joints of 2024-T3 sustain high mechanical loadings. Investigations on the corrosion properties reveal a certain sensitivity of the 2024-T3 joints to intergranular and exfoliation corrosion.
    Notes: Das Reibrührschweißen (friction stir welding FSW) ist ein neues Fügeverfahren, mit dem auch die schwer schmelzschweißbaren, höherfesten Aluminiumlegierungen ohne große Festigkeitsverluste verschweißt werden können. Erste Ergebnisse von Untersuchungen an selbst hergestellten FSW-Stumpfnähten der Aluminiumlegierungen 2024-T3 und 6013-T4 werden vorgestellt. Zunächst wird das Gefüge der Naht und der Wärmeeinflußzone mikrostrukturell und durch Härteverläufe charakterisiert. Weiterhin wird mit Zug-, Schwingfestigkeits- und Rißfortschrittsversuchen nachgewiesen, daß insbesondere die FSW-Nähte der Legierung 2024-T3 außerordentlich hohe mechanische Belastungen ertragen. Abschließende Korrosionsuntersuchungen der FSW-Nähte zeigen eine gewisse Anfälligkeit der abschreckempfindlichen Legierung 2024-T3 für interkristalline Korrosion und Schichtkorrosion.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 15 (1992), S. 71-74 
    ISSN: 0935-6304
    Keywords: On-line coupled LC-GC ; Loop-type interface ; Mixing in the sample loop ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: During introduction of an LC fraction into the sample loop of the loop-type interface mixing occurs between the fraction of interest and the material previously eluted from the LC. Such mixing may not only result in losses of the solute material of interest, but also in contamination of the fraction of interest with material from which it was supposed to have been isolated. Experimental determination of the extent of mixing has led to the conclusion that whereas the effects are negligible under some conditions, in some circumstances the mixing can cause severe problems.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 17 (1836), S. 191-192 
    ISSN: 0365-5490
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 20 (1836), S. 71-73 
    ISSN: 0365-5490
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2019-03-01
    Description: Understanding the trigger mechanisms of phreatic eruptions is key to mitigating the effects of these hazardous but poorly forecastable volcanic events. It has recently been established that high-rate volcanic gas observations are potentially very suitable to identifying the source processes driving phreatic eruptions, and to eventually detecting precursory changes prior to individual phreatic blasts. In February-May 2017, we deployed a Multi-GAS instrument to continuously monitor gas concentrations in the crater lake plume of Rincón de la Vieja, a remote and poorly monitored active volcano in Costa Rica, site of frequent phreatic/phreatomagmatic eruptions. Forty-two phreatic/phreatomagmatic eruptions were seismically recorded during our investigated period, 9 of which were also recorded for gas by the Multi-GAS. To the best of our knowledge, these represent the first instrumentally measured gas compositions during individual phreatic/phreatomagmatic explosions at an active volcano. Our results show that during background quiescent degassing the Rincón de la Vieja crater lake plume was characterized by high CO2/SO2 ratios of 64 ± 59 and H2S/SO2 ratios of 0.57 ± 0.20. This composition is interpreted as reflecting hydrothermal (re)processing of magma-sourced gas in the sub-limnic environment. Phreatic blasts were recorded by the Multi-GAS as brief (1–2 min long) pulses of elevated gas mixing ratios (up to ~52 ppmv SO2 and 〉3,000 ppmv CO2), or more than an order of magnitude higher than during background degassing (~1 ppmv SO2 and ~450 ppmv CO2). During the phreatic eruption(s), the H2S/SO2 ratio was systematically lower (〈0.18) than during background degassing, but the CO2/SO2 ratio remained high (and variable), ranging from 37 to 390. These S-poor compositions for the eruptive gas imply extensive processing of the source magmatic gas during pre-eruptive hydrothermal storage, likely by deposition of native S and/or sulfate. Our gas results are thus overall consistent with a mechanism of phreatic eruptions triggered by accumulation of magmatic-hydrothermal gases beneath a hydrothermal seal. We claim that real-time Multi-GAS monitoring is urgently needed at other crater lake-hosting volcanoes (e.g., Ruapehu, Aso), where phreatic eruptions may similarly be preceded by phases of reduced S degassing at the surface.
    Description: Published
    Description: Article 247
    Description: 4V. Dinamica dei processi pre-eruttivi
    Description: JCR Journal
    Keywords: volcanic gases ; crater lakes ; rincon de la vieja ; multi-GAS ; 04.08. Volcanology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 7
    Publication Date: 2019-01-24
    Description: The advent of UV cameras has recently paved the way to volcanic SO2 flux observations of much improved temporal and spatial resolution, and has thus contributed to expanding use and utility of SO2 fluxes in volcano monitoring. Recently, the first examples of permanent UV camera systems have appeared that are now opening the way to routine fully automated monitoring of the volcanic SO2 flux at high-rate, and continuously (daily hours only). In 2014, using funding from the FP7-ERC project “Bridge” (http://www.bridge.unipa.it/), we deployed a network of 4 permanent UV cameras at Etna and Stromboli volcanoes (Sicily) that has been operating regularly since then. Using a suite of custom-built codes, data streamed by the UV camera are automatically processed and telemetered, allowing nearly real-time visualization and analysis of SO2 fluxes. Here, we summarise the key results obtained during the last 5 years of continuous observations (2014-2018) to demonstrate potentials and challenges in real-time continuous SO2 flux monitoring with UV cameras. We show that the spatially resolved SO2 flux time-series delivered by the UV camera allow effectively tracking migration in volcanic activity from the Central to New South-East Crater (Etna), and shifts in degassing activity along the crater terrace (Stromboli). At both volcanoes, the high temporal of UV cameras allows capturing the escalation in active (strombolian) SO2 degassing that typically precedes onset of paroxysmal (Etna in 2014-2016) or effusive (Stromboli in 2014) activity, and to quantify for the first time the syn- explosive SO2 budget for larger-scale explosions, including 2 paroxysmal lava fountains (Etna) and 1 major explosion (Stromboli). We finally demonstrate the ability of our automatic camera systems to capture temporal changes in SO2 flux regime, and thus to “live” monitoring degassing and eruptive behaviors at active volcanoes.
    Description: Published
    Description: Napoli
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Keywords: UV Camera ; SO2 Flux Monitoring ; Etna ; Stromboli
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
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  • 8
    Publication Date: 2019-01-24
    Description: The persistent open-vent activity of basaltic volcanoes is periodically interrupted by spectacular but hazardous paroxysmal explosions. The rapid transition from quiescence to explosive eruption poses a significant challenge for volcanic hazard assessment and mitigation, and improving our understanding of the processes that trigger these paroxysmal events is critical. Although magmatic gas is unquestionably the driver, direct measurements of a paroxysm's gas flux budget have remained challenging, to date. A particularly violent paroxysmal sequence took place on Etna on December 2015, intermittently involving all summit craters, especially the Voragine (VOR) that had previously displayed no activity for several years. Here, we characterize the volcano's SO2 degassing budget prior to, during and after this paroxysmal sequence, using ground-based (UV-Camera) and satellite (OMI) observations, complemented with ground- and space-borne thermal measurements. We make use of the high spatial resolution of UV-cameras to resolve SO2 emissions from the erupting VOR crater for the first time, and to characterize temporal switches in degassing activity from VOR to the nearby New Southeast Crater (NSEC). Our data show that onset of paroxysmal activity on December 3–5 was marked by visible escalation in VOR SO2 fluxes (4,700–8,900 tons/day), in satellite-derived thermal emissions (2,000 MW vs. ~2–11 MW in July-November 2015), and in OMI-derived daily SO2 masses (5.4 ± 0.7 to 10.0 ± 1.3 kilotonnes, kt; 0.5 kt was the average in the pre-eruptive period). Switch in volcanic activity from VOR to NSEC on December 6 was detected by increasing SO2 fluxes at the NSEC crater, and by decaying SO2 emissions at VOR, until activity termination on December 19. Taken together, our observations infer the total degassed SO2 mass for the entire VOR paroxysmal sequence at 21,000 ± 2,730 t, corresponding to complete degassing of ~1.9 ± 0.3 Mm3 of magma, or significantly less than the measured erupted magma volumes (5.1–12 Mm3). From this mismatch we propose that only a small fraction of the erupted magma was actually emplaced in the shallow plumbing system during (or shortly prior) the paroxysmal sequence. Rather, the majority of the erupted magma was likely stored conduit magma, having gone through extensive degassing for days to weeks prior to the paroxysm.
    Description: Published
    Description: id 239
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Keywords: volcanic SO2 ; UV camera ; thermal remote sensing ; Etna ; basaltic paroxysms ; OMI
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2024-01-25
    Description: The persistent open-vent degassing of Mt. Etna is often punctuated by monthslong paroxysmal sequences characterized by episodes of violent Strombolian to lava fountaining activity. Understanding these gas-fueled transitions from quiescence to eruption requires routine measurement of gas fluxes. Here, we report SO2 flux measurements, obtained from a permanent UV camera system, collected over a two-year-long period spanning two paroxysmal sequences of Etna’s New South East Crater (NSEC) in December 2020/April 2021 and May/ October 2021. In both cases, SO2 flux increased from ≤ 3250 Mg/day during “ordinary” activity to ≥ 4200 Mg/day. We interpret these distinct SO2 degassing regimes in light of seismic and thermal observations and drawing on numerical simulations of sulfur degassing constrained by parental melt sulfur contents in Etna’s hawaiites. We find that initiation of a paroxysmal sequence results from an approximate doubling of the time-averaged rate of magma supply (and degassing) above the sulfur exsolution level (~150 MPa pressure), to 〉4m3/s. This corroborates recent models that argue for the triggering of paroxysmal sequences by escalating supply of volatile-rich magma to a reservoir ~3–4 km below the summit region. The non-stationary nature of magma flow and volcanic degassing we identify highlights the need for sustained surveillance to characterize long-term atmospheric budgets of volcanic volatiles
    Description: Published
    Description: 1115111
    Description: OSV2: Complessità dei processi vulcanici: approcci multidisciplinari e multiparametrici
    Description: JCR Journal
    Keywords: Etna, ; volcanic gases ; SO2 flux ; paroxysms ; UV Camera ; basaltic explosive volcanism ; 04.08. Volcanology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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