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Characterization of the membrane-associated GTPase activity: Effects of chemotactic factors and toxins (1989)

Pelz, Claudia ; Matsumoto, Tadashi ; Molski, Thaddeus F. P. ; [et al.]

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 39 (1989), S. 197-206

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ISSN: 0730-2312

Keywords: neutrophil ; GTPase ; fMet-Leu-Phe ; leukotriene ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Membranes prepared from rabbit neutrophils exhibit GTPase activity which can be stimulated by the chemotactic factor fMet-Leu-Phe. The maximum contribution of the ATPase activities to the basal and the fMet-Leu-Phe-stimulated GTPase activities are less than 20% and 9%, respectively. The basal GTPase activity has a Vmax = 34.2 ± 1.3 (pmol/mg protein, min) and a Km = 0.39 ± 0.03 μM; and the fMet-Leu-Phe-stimulated has a Vmax = 52.3 ± 2.5 (pmol/mg protein, min), and a Km = 0.29 ± 0.02 μM. The GTPase activity can be stimulated by fMet-Leu-Phe and leukotriene B4. Unlike these two chemotactic factors, concanavalin A does not stimulate this GTPase activity. In addition, the rise in intracellular concentration of free calcium produced by concanavalin A is not inhibited by pertussis toxin treatment. Both the basal and stimulated GTPase activities are affected by pertussis toxin, cholera toxin and N-ethylmaleimide.

Additional Material: 6 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jcb.240390211

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A severe case of Moebius syndrome with calcification on the fourth ventricular floor (1998)

Matsunaga, Y. ; Amamoto, Nagisa ; Kondoh, Tatsuro ; [et al.]

Springer

Journal of human genetics 43 (1998), S. 62-64

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ISSN: 1435-232X

Keywords: Key words Moebius syndrome ; Calcification ; Arthrogryposis multiplex congenita ; Blood supply disturbance

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract We report the case of a Japanese girl with a severe type of Moebius syndrome. Her morphological features were a mask-like face, limitation of horizontal eye movements, severe bulbar palsy, multiple and bilateral arthrogryposis including the elbow, knee, and ankle joints, and clubfeet. After birth, her general condition became worse because of repeated apneic spells and aspiration pneumonias due to dysphagia. She finally required tracheotomy. Computed tomography (CT) of the brain revealed minute calcifications on the fourth ventricle floor; this may have been due to severe damage to the brain stem. It is most likely that the various manifestations in our patient were due to disturbance of the blood supply to arteries perfusing the brain stem and to some other arteries, at a critical stage of fetal development.