Publication Date:
2007-08-04
Description:
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX(3)CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Auffray, Cedric -- Fogg, Darin -- Garfa, Meriem -- Elain, Gaelle -- Join-Lambert, Olivier -- Kayal, Samer -- Sarnacki, Sabine -- Cumano, Ana -- Lauvau, Gregoire -- Geissmann, Frederic -- G0900867/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2007 Aug 3;317(5838):666-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Nationale de la Sante et de la Recherche Medicale (INSERM) U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker-Enfants Malades, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17673663" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood Vessels/*immunology
;
Cell Adhesion
;
Cell Differentiation
;
Cell Movement
;
Dermis/immunology
;
Endothelium, Vascular/*immunology
;
Gene Expression Regulation
;
Immunity, Innate
;
Inflammation/*immunology
;
Listeria monocytogenes
;
Listeriosis/immunology
;
Lymphocyte Function-Associated Antigen-1/physiology
;
Macrophages/cytology/immunology
;
Mesenteric Arteries/immunology
;
Mesenteric Veins/immunology
;
Mice
;
Microscopy, Confocal
;
Monocytes/cytology/*immunology/physiology
;
Receptors, Chemokine/analysis/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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