Publication Date:
2006-03-25
Description:
A cure for type 1 diabetes will probably require the provision or elicitation of new pancreatic islet beta cells as well as the reestablishment of immunological tolerance. A 2003 study reported achievement of both advances in the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic spleen cells. It was concluded that the adjuvant eliminated anti-islet autoimmunity and the donor splenocytes differentiated into insulin-producing (presumably beta) cells, culminating in islet regeneration. Here, we provide data indicating that the recovered islets were all of host origin, reflecting that the diabetic NOD mice actually retain substantial beta cell mass, which can be rejuvenated/regenerated to reverse disease upon adjuvant-dependent dampening of autoimmunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishio, Junko -- Gaglia, Jason L -- Turvey, Stuart E -- Campbell, Christopher -- Benoist, Christophe -- Mathis, Diane -- T32 CA09382/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2006 Mar 24;311(5768):1775-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16556845" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies/immunology
;
Autoimmunity
;
Blood Glucose/analysis
;
Cell Differentiation
;
*Cell Transplantation
;
Combined Modality Therapy
;
Diabetes Mellitus, Type 1/immunology/pathology/*therapy
;
Female
;
Freund's Adjuvant/*therapeutic use
;
Insulin-Secreting Cells/*cytology
;
Islets of Langerhans/*cytology/pathology
;
*Islets of Langerhans Transplantation
;
Male
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, Inbred NOD
;
Polymorphism, Single Nucleotide
;
Regeneration
;
Spleen/*cytology/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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