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  • Biomedical Research.  (1)
  • Drosophila melanogaster  (1)
  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Genetics. ; Medicine Research. ; Biology Research. ; Cytology. ; Medical genetics. ; Genetics and Genomics. ; Biomedical Research. ; Cell Biology. ; Medical Genetics.
    Description / Table of Contents: Biology of Chromatin -- Chromatin Dynamics -- Cellular Memory -- Dosage Compensation Systems -- Genomic Imprinting -- RNA-based Mechanisms of Gene Silencing -- Regeneration and Reprogramming -- Epigenetics and Cancer -- Epigenetics and Metabolism.
    Abstract: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease.
    Type of Medium: Online Resource
    Pages: XII, 215 p. 81 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030686703
    Series Statement: Learning Materials in Biosciences,
    DDC: 576.5
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Chromosome research 3 (1995), S. 351-360 
    ISSN: 1573-6849
    Keywords: chromatin ; Drosophila melanogaster ; Polycomb ; silencing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract InDrosophila the Polycomb group (Pc-G) proteins are responsible for the stable and heritable silencing of genes. The Pc-G apparently uses heterochromatin-like mechanisms to transcriptionally inactivate developmental regulators such as the homeotic genes. The Polycomb (Pc) protein is part of a large multimeric complex composed of other members of the Pc-G. We have identified functionally relevant domains of the Pc protein by sequencing differentPc alleles. Additionally, using a Pc-βgal fusion protein with deleted internal histidine repeats, we found that this mutant protein cannot bind to four particular target loci, but otherwise does not change the remaining overall binding pattern. We show that, in contrast to the dotted subnuclear localization of the wild-type protein, the nuclear distribution of mutant proteins becomes homogeneous. Surprisingly, inPc mutants the polyhomeotic protein, another member of the Pc-G, is also redistributed in the nucleus. Our results indicate that the appropriate subnuclear localization of the two proteins is critical for the silencing function of the Pc-G complex.
    Type of Medium: Electronic Resource
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