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  • Biomedical Research.  (1)
  • Drosophila development  (1)
  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Genetics. ; Medicine Research. ; Biology Research. ; Cytology. ; Medical genetics. ; Genetics and Genomics. ; Biomedical Research. ; Cell Biology. ; Medical Genetics.
    Description / Table of Contents: Biology of Chromatin -- Chromatin Dynamics -- Cellular Memory -- Dosage Compensation Systems -- Genomic Imprinting -- RNA-based Mechanisms of Gene Silencing -- Regeneration and Reprogramming -- Epigenetics and Cancer -- Epigenetics and Metabolism.
    Abstract: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease.
    Type of Medium: Online Resource
    Pages: XII, 215 p. 81 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030686703
    Series Statement: Learning Materials in Biosciences,
    DDC: 576.5
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 15 (1994), S. 478-484 
    ISSN: 0192-253X
    Keywords: Drosophila development ; transcription regulation ; pattern formation ; chromatin structure ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In early Drosophila development a complex cascade of diffusible transcription factors generates an intricate expression pattern of developmental regulators such as the homeotic genes. The mechanism which subsequently maintains the pattern during the rest of development is mainly using epigenetic features for its function. Evidence comes from the analysis of the Polycomb-group (Pc-G), a class of genes which is responsible for maintaining the inactive state of expression. The Pc-G was found to share many parallels to genes involved in heterochromatin formation. Different members of the Pc-G interact in large multiprotein complexes, which apparently can cover and inactivate large chromosomal domains. Specific DNA elements have been identified that are used by the Pc-G proteins to nucleate these specialized domains of silent chromatin. Thus, the Pc-G proteins appear to permanently inactivate genes by generating heterochromatin-like structures which could then be inherited by the daughter cells in an epigenetic manner. Heritable gene silencing is an important but little understood mechanism in pattern formation. Phenomenologically related effects have been observed in many organisms. These range from the transcriptional silencing of the inactive mating type loci in yeast to parental imprinting phenomena and X-chromosome inactivation in mammals. Analysis of these functions in Drosophila provides an excellent model system for studying the molecular basis of such epigenetic mechanisms that use higher order chromatin structures for transcriptional repression. © 1994 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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