Publication Date:
1995-05-12
Description:
Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kanai, N -- Lu, R -- Satriano, J A -- Bao, Y -- Wolkoff, A W -- Schuster, V L -- DK-38095/DK/NIDDK NIH HHS/ -- DK23026/DK/NIDDK NIH HHS/ -- DK41296/DK/NIDDK NIH HHS/ -- R01 DK049688/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1995 May 12;268(5212):866-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754369" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
*Antiporters
;
Base Sequence
;
Biological Transport/drug effects
;
Carrier Proteins/chemistry/genetics/*metabolism
;
Codon
;
Colon/metabolism
;
DNA, Complementary/genetics
;
DNA-Binding Proteins/chemistry/genetics/*metabolism
;
Epithelium/metabolism
;
HeLa Cells
;
Humans
;
Kidney Medulla/metabolism
;
Molecular Sequence Data
;
Organic Anion Transporters
;
Prostaglandins/*metabolism
;
RNA, Messenger/analysis
;
Rats
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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