ISSN:
1573-1561
Keywords:
Platyphylloside
;
5-hydroxy-3-platyphyllone
;
centrolobol
;
phenols
;
rumen fluid
;
birch bark
;
Betula pendula
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract (±)-5-Hydroxy-1,7-bis-(4′-hydroxyphenyl)-3-heptanone (2a), (±)-5-hydroxyl-1-(4′-hydroxyphenyl)-7-phenyl-3-heptanone (2b), (±)-5-hydroxy-7-(4′-hydroxyphenyl)-1-phenyl-3-heptanone (2c), and (±)-5-hydroxy-1,7-bis-(phenyl)-3-heptanone (2d) have been synthesized to study the structure–activity relationship regarding digestibility inhibition in vitro in cow rumen fluid. The activities were compared with the activity of chiral (S)-2a and its glucoside platyphylloside (1), isolated from Betula pendula. Compound 2a was slightly less active, 2b and 2c were more active, and 2d was less active than (S)-2a and platyphylloside.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1020847423427
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