Publication Date:
1978-01-27
Description:
Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Rowe, H -- Carmichael, R -- Oldham, S -- Horng, J S -- Bymaster, F P -- Wong, D T -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):436-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619465" target="_blank"〉PubMed〈/a〉
Keywords:
Behavior/drug effects
;
Blood Platelets/*drug effects/metabolism
;
Blood Pressure/drug effects
;
Humans
;
Norepinephrine/pharmacology
;
Phenyl Ethers/pharmacology
;
Propylamines/*pharmacology
;
Serotonin/*blood
;
Serotonin Antagonists/pharmacology
;
Tyramine/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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