Publication Date:
1989-04-07
Description:
An algorithm and a computer program have been prepared for determining RNA secondary structures within any prescribed increment of the computed global minimum free energy. The mathematical problem of determining how well defined a minimum energy folding is can now be solved. All predicted base pairs that can participate in suboptimal structures may be displayed and analyzed graphically. Representative suboptimal foldings are generated by selecting these base pairs one at a time and computing the best foldings that contain them. A distance criterion that ensures that no two structures are "too close" is used to avoid multiple generation of similar structures. Thermodynamic parameters, including free-energy increments for single-base stacking at the ends of helices and for terminal mismatched pairs in interior and hairpin loops, are incorporated into the underlying folding model of the above algorithm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zuker, M -- New York, N.Y. -- Science. 1989 Apr 7;244(4900):48-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2468181" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Molecular Sequence Data
;
*Nucleic Acid Conformation
;
*Rna
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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