ISSN:
0170-2041
Keywords:
Pyrrolo[2,3-d]pyrimidines
;
2′,3′-Dideoxyribonucleosides
;
Barton deoxygenation
;
HIV, potential agent against
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A number of new 2-aminopyrrolo[2,3-d]pyrimidine N-7-(2′,3′-dideoxyribonucleosides) (11-13 and 15) were synthesized. These are related to 7-deaza-2′,3′-dideoxyguanosine (14), but carry various substituents at C-4. 2-Amino-4-chloro-7-(2′,3′-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolo[2,3-d]-pyrimidine (3) was used as a common intermediate, and was obtained from the corresponding 2′-deoxyribonucleoside 4 by selective silylation of 5′-OH and Barton deoxygenation of 3′-OH.
Additional Material:
13 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199019900141
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