Publikationsdatum:
2006-08-05
Beschreibung:
Almost every vertebrate cell has a specialized cell surface projection called a primary cilium. Although these structures were first described more than a century ago, the full scope of their functions remains poorly understood. Here, we review emerging evidence that in addition to their well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in intercellular signaling. This new appreciation of primary cilia as cellular antennae that sense a wide variety of signals could help explain why ciliary defects underlie such a wide range of human disorders, including retinal degeneration, polycystic kidney disease, Bardet-Biedl syndrome, and neural tube defects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singla, Veena -- Reiter, Jeremy F -- R21 DK069423/DK/NIDDK NIH HHS/ -- R21DK69423/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2006 Aug 4;313(5787):629-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Developmental and Stem Cell Biology, and Diabetes Center, University of California, San Francisco, CA 94143-0525, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16888132" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Bardet-Biedl Syndrome/pathology/physiopathology
;
Biological Evolution
;
Cell Polarity
;
Cilia/*physiology
;
Hedgehog Proteins
;
Humans
;
Mechanoreceptors/physiology
;
Models, Biological
;
Neural Tube Defects/pathology/physiopathology
;
Polycystic Kidney Diseases/pathology/physiopathology
;
Retinal Degeneration/pathology/physiopathology
;
*Signal Transduction
;
Smell/physiology
;
Trans-Activators/metabolism
;
Vision, Ocular/physiology
;
Wnt Proteins/metabolism
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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